home > drugs a-z list > thyrel trh (protirelin) drug center > thyrel trh (protirelin) drug - side effects and drug interactions

Side effects have been reported in about 50% of the patients tested with Thyrel TRH (protirelin) . Generally, the side effects are minor, have occurred promptly, and have persisted for only a few minutes following injection.

Cardiovascular reactions:

Marked changes in blood pressure, including both hypertension and hypotension with or without syncope, have been reported in a small number of patients.

Endocrine reaction:

Breast enlargement and leakage in lactating women for up to two or three days.

Other reactions:

Headaches, sometimes severe, and transient amaurosis in patients with pituitary tumors. Rarely, convulsions may occur in patients with predisposing conditions, e.g., epilepsy, brain damage. Nausea; urge to urinate; flushed sensation; lightheadedness; bad taste in mouth; abdominal discomfort; and dry mouth. Less frequently reported were: Anxiety; sweating; tightness in the throat; pressure in the chest; tingling sensation; drowsiness; and allergic reactions.

Pituitary apoplexy requiring acute neurosurgical intervention has been reported infrequently for patients with pituitary macroadenomas following the acute administration of protirelin injection in the setting of combined anterior pituitary function testing in conjunction with LHRH and insulin.

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Last reviewed on RxList: 1/18/2005
This monograph has been modified to include the generic and brand name in many instances.