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Thyrel Trh

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Thyrel Trh

Discontinued Warning IconPlease Note: This Brand Name drug is no longer available in the US.
(Generic versions may still be available.)

Thyrel Trh Side Effects Center

Medical Editor: John P. Cunha, DO, FACOEP

Last reviewed on RxList 5/12/2016

Thyrel TRH (protirelin) is a diagnostic agent used to assess thyroid, pituitary, or hypothalamic dysfunction. The brand name Thyrel TRH is discontinued, but generic versions may be available. Common side effects of Thyrel TRH (protirelin) include:

  • dry mouth
  • dizziness
  • changes in taste or unpleasant taste in the mouth
  • redness of the face of neck (flushing)
  • headache
  • nausea
  • frequent urination
  • stomach cramps
  • abdominal discomfort
  • changes in blood pressure
  • breast enlargement
  • lightheadedness
  • anxiety
  • sweating
  • tightness in the throat
  • pressure in the chest
  • tingling sensation
  • drowsiness, and
  • allergic reactions

The adult dosage of Thyrel TRH is 500 g. The dose for children age 6 to 16 years is 7 g/kg body weight up to dose of 500 g. Thyrel TRH may interact with other drugs. Tell your doctor all medications and supplements you use. During pregnancy, Thyrel TRH should be used only if prescribed. It is unknown if this drug passes into breast milk. Consult your doctor before breastfeeding.

Our Thyrel TRH (protirelin) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is Prescribing information?

The FDA package insert formatted in easy-to-find categories for health professionals and clinicians.

Thyrel Trh FDA Prescribing Information: Side Effects
(Adverse Reactions)


Side effects have been reported in about 50% of the patients tested with Thyrel TRH (protirelin) . Generally, the side effects are minor, have occurred promptly, and have persisted for only a few minutes following injection.

Cardiovascular reactions:

Marked changes in blood pressure, including both hypertension and hypotension with or without syncope, have been reported in a small number of patients.

Endocrine reaction:

Breast enlargement and leakage in lactating women for up to two or three days.

Other reactions:

Headaches, sometimes severe, and transient amaurosis in patients with pituitary tumors. Rarely, convulsions may occur in patients with predisposing conditions, e.g., epilepsy, brain damage. Nausea; urge to urinate; flushed sensation; lightheadedness; bad taste in mouth; abdominal discomfort; and dry mouth. Less frequently reported were: Anxiety; sweating; tightness in the throat; pressure in the chest; tingling sensation; drowsiness; and allergic reactions.

Pituitary apoplexy requiring acute neurosurgical intervention has been reported infrequently for patients with pituitary macroadenomas following the acute administration of protirelin injection in the setting of combined anterior pituitary function testing in conjunction with LHRH and insulin.


Read the entire FDA prescribing information for Thyrel Trh (Protirelin)

Report Problems to the Food and Drug Administration


You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

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