Tigan (Trimethobenzamide Hydrochloride Capsules) Drug Information: Description, User Reviews, Drug Side Effects, Interactions

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February 9, 2012

Tigan

Nausea and Vomiting »

Introduction to nausea and vomiting

Nausea and vomiting are symptoms of an underlying disease and not a specific illness. Nausea is the sensation that the stomach wants to empty itself, while vomiting (emesis) or throwing up, is the act of forcible emptying of the stomach.

Vomiting is a violent act in which the stomach has to overcome the pressures that are normally in place to keep food and secretions within the stomach. The stomach almost turns itself inside out - forcing itself into the lower portion of the esophagus (the tube that connects the mouth to the stomach) during a vomiting episode.

What causes nausea or vomiting?

There are numerous causes of nausea and vomiting. These symptoms may be due to the following:

acute gastritis
central causes (signals from the brain)
association with other illnesses remote from the stomach
medications and medical treatments

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Tigan®
(trimethobenzamide hydrochloride) Capsules

DRUG DESCRIPTION

Chemically, trimethobenzamide HCl is N-[p-[2-(dimethylamino)ethoxy]benzyl]-3,4,5trimethoxybenzamide monohydrochloride. It has a molecular weight of 424.93 and the following structural formula:

Tigan® (trimethobenzamide hydrochloride) Structural Formula Illustration

Capsules: Each 300-mg Tigan (trimethobenzamide hydrochloride capsules) capsule for oral use contains trimethobenzamide hydrochloride equivalent to 300 mg. The capsule has an opaque purple cap marked “Tigan (trimethobenzamide hydrochloride capsules) ” and an opaque purple body marked “M079”. Inactive Ingredients: D&C Red No. 28, FD&C Blue No. 1, lactose, magnesium stearate, starch and titanium dioxide.

What are the possible side effects of trimethobenzamide (Tigan)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using this medication and call your doctor at once if you have any of these serious side effects:

jaundice (yellowing of the skin or eyes);
seizure (convulsions);
easy bruising or bleeding, unusual weakness;
tremor (uncontrolled shaking); or
muscle cramps, severe muscle spasms.

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What are the precautions when taking trimethobenzamide hydrochloride capsules (Tigan)?

Before taking trimethobenzamide, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: high fever, kidney problems, stomach/intestinal problems (e.g., appendicitis), swelling/disease of the brain (encephalitis/encephalopathy), a serious loss of body water (dehydration), mineral (electrolyte) imbalance.

This drug may make you dizzy or drowsy or cause blurred vision. Do not drive, use machinery, or do any activity that requires alertness or clear vision until you are sure you can perform such...

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Last reviewed on RxList: 1/23/2009
This monograph has been modified to include the generic and brand name in many instances.