"The U.S. Food and Drug Administration today approved Dotarem (gadoterate meglumine) for use in magnetic resonance imaging (MRI) of the brain, spine and associated tissues of patients ages 2 years and older.
Dotarem is a gadolinium-based"...
(trimethobenzamide hydrochloride) Injectable
For Intramuscular Use Only
Not for Use in Pediatric Patients
Chemically, trimethobenzamide HCl is N-[p-[2-(dimethylamino)ethoxy]benzyl]-3,4,5-trimethoxybenzamide monohydrochloride. It has a molecular weight of 424.93 and the following structural formula:
Single-Dose Vials: Each 2-mL single-dose vial contains 200 mg trimethobenzamide hydrochloride compounded with 1 mg sodium citrate and 0.4 mg citric acid as buffers and pH adjusted to approximately 5.0 with sodium hydroxide.
Multi-Dose Vials: Each mL contains 100 mg trimethobenzamide hydrochloride compounded with 0.45% phenol as preservative, 0.5 mg sodium citrate and 0.2 mg citric acid as buffers and pH adjusted to approximately 5.0 with sodium hydroxide.
What are the possible side effects of trimethobenzamide (Tigan)?
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Stop using this medication and call your doctor at once if you have any of these serious side effects:
- jaundice (yellowing of the skin or eyes);
- seizure (convulsions);
- easy bruising or bleeding, unusual weakness;
- tremor (uncontrolled shaking); or
- muscle cramps, severe muscle spasms.
Continue using trimethobenzamide and talk with your doctor if you have any of...
What are the precautions when taking trimethobenzamide hydrochloride injectable (Tigan Injection)?
Last reviewed on RxList: 8/26/2008
This monograph has been modified to include the generic and brand name in many instances.
Additional Tigan Injection Information
Tigan Injection - User Reviews
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
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