Tikosyn (Dofetilide) Patient Information: Missed a Dose and What Should I Avoid at RxList

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May 27, 2012

Tikosyn

Atrial Fibrillation »

What is atrial fibrillation?

Atrial fibrillation (AF) is the most common, abnormal rhythm of the heart.

The heart contracts (beats) and pumps blood with a regular rhythm, for example, at a rate of 60 beats per minute there is a beat every second. The heart may beat faster or slower with a shorter or longer interval between beats, but at any one rate the interval between beats is constant. This regular rhythm occurs as a result of regular electrical discharges (currents) that travel through the heart and cause the muscle of the heart to contract. In atrial fibrillation, the electrical discharges are irregular and rapid and, as a result, the heart beats irregularly and, usually, rapidly.

Atrial fibrillation is common; half a million new cases are diagnosed yearly in the U.S., and billions of dollars are spent annually on its diagnosis and treatment.

What causes atrial fibrillation?

Normal function of the he...

Read the Atrial Fibrillation article »

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Tikosyn Patient Information including If I Miss a Dose

What happens if I miss a dose (Tikosyn)?

Take the missed dose as soon as you remember. If it is almost time for your next dose, wait until then to take the medicine and skip the missed dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose (Tikosyn)?

Seek emergency medical attention if you think you have used too much of this medicine.

Overdose symptoms may include slow or fast heartbeats, shortness of breath, chest pain, feeling light-headed, or fainting.

What should I avoid while taking dofetilide (Tikosyn)?

Grapefruit and grapefruit juice may interact with dofetilide and lead to potentially dangerous effects. Discuss the use of grapefruit products with your doctor. Do not increase or decrease the amount of grapefruit products in your diet without first talking to your doctor.

What other drugs will affect dofetilide (Tikosyn)?

Many drugs can interact with dofetilide. Below is just a partial list. Tell your doctor if you are using:

a diuretic (water pill);
HIV/AIDS medicine such as nelfinavir (Viracept) or ritonavir (Norvir);
drugs that can affect heart rhythm, such as bepridil (Vascor), cisapride (Propulsid), droperidol (Inapsine);
narcotic medication such as levomethadyl (Orlaam), or methadone (Dolophine, Methadose);
antibiotics such as clarithromycin (Biaxin), erythromycin (E-Mycin, E.E.S., Erythrocin, Ery-Tab), levofloxacin (Levaquin), moxifloxacin (Avelox), or pentamidine (NebuPent, Pentam);
an antidepressant such as amitriptyline (Elavil, Etrafon), desipramine (Norpramin), fluoxetine (Prozac), fluvoxamine (Luvox), imipramine (Janimine, Tofranil), or paroxetine (Paxil);
medicines to treat psychiatric disorders, such as chlorpromazine (Thorazine), haloperidol (Haldol), mesoridazine (Serentil), or thioridazine (Mellaril); or
heart rhythm medicine such as amiodarone (Cordarone, Pacerone), disopyramide (Norpace), ibutilide (Corvert), procainamide (Procan, Pronestyl), quinidine (Quinidex, Quin-Release Quin-G), or sotalol (Betapace).

This list is not complete and there may be other drugs that can interact with dofetilide. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor. Keep a list with you of all the medicines you use and show this list to any doctor or other healthcare provider who treats you.

Where can I get more information?

Your pharmacist can provide more information about dofetilide.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

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