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(ticarcillin disodium and clavulanate potassium) For Injection
TIMENTIN (ticarcillin disodium and clavulanate potassium) for Injection, 3.1-gram glass vial, 31-gram Pharmacy Bulk Package, and TIMENTIN (ticarcillin disodium and clavulanate potassium) for Injection in the GALAXY bag are a combination of ticarcillin disodium and the b-lactamase inhibitor clavulanate potassium (the potassium salt of clavulanic acid) for intravenous administration. Ticarcillin is derived from the basic penicillin nucleus, 6-amino-penicillanic acid.
Chemically, ticarcillin disodium is N-(2-Carboxy-3,3-dimethyl-7-oxo-4-thia-1- azabicyclo[3.2.0]hept-6-yl)-3-thiophenemalonamic acid disodium salt and may be represented as:
Clavulanic acid is produced by the fermentation of Streptomyces clavuligerus. It is a β-lactam structurally related to the penicillins and possesses the ability to inactivate a wide variety of β-lactamases by blocking the active sites of these enzymes. Clavulanic acid is particularly active against the clinically important plasmid-mediated P-lactamases frequently responsible for transferred drug resistance to penicillins and cephalosporins.
Chemically, clavulanate potassium is potassium (Z)-(2R,5R)-3-(2-hydroxyethylidene)-7- oxo-4-oxa-l-azabicyclo[3.2.0]heptane-2-carboxylate and may be represented structurally as:
TIMENTIN (ticarcillin disodium and clavulanate potassium) for Injection, the 3.1-gram glass vial or the 31-gram Pharmacy Bulk Package, are white to pale yellow sterile powders to be reconstituted and diluted for intravenous infusion. The reconstituted solution is clear, colorless or pale yellow, with a pH of 5.5 to 7.5. The 3.1-gram glass vial of TIMENTIN for Injection contains ticarcillin disodium equivalent to 3 grams ticarcillin and clavulanate potassium equivalent to 0.1 gram clavulanic acid. The 31-gram TIMENTIN for Injection Pharmacy Bulk Package contains ticarcillin disodium equivalent to 30 grams ticarcillin and clavulanate potassium equivalent to 1 gram clavulanic acid.
TIMENTIN (ticarcillin disodium and clavulanate potassium) Injection in GALAXY bag is an iso-osmotic, sterile, nonpyrogenic, frozen solution containing 3.0 grams ticarcillin as ticarcillin disodium and 0.1 gram clavulanic acid as clavulanate potassium and approximately 0.3 gram sodium citrate hydrous as a buffer. The solution is intended for intravenous use after thawing to room temperature. The pH of thawed solution ranges from 5.5 to 7.5. For the 3.1 gram dosage of TIMENTIN, the theoretical sodium content is 4.51 mEq (103.6 mg) per gram of TIMENTIN. The theoretical potassium content is 0.15 mEq (6 mg) per gram of TIMENTIN.
Last reviewed on RxList: 10/16/2012
This monograph has been modified to include the generic and brand name in many instances.
Additional Timentin Injection Information
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