"Dec. 18, 2012 -- People who can't get their high blood pressure down with drugs may be helped by a new procedure that deactivates overactive nerves in the kidneys, a small study shows.
The procedure is already available in Europe and "...
(Generic versions may still be available.)
TIMOLIDE* (Timolol Maleate-Hydrochlorothiazide) is for the treatment of hyper-tension. It combines the antihyper-tensive activity of two agents: a non-selective beta-adrenergic receptor blocking agent (timolol maleate) and a diuretic (hydrochlorothiazide).
Timolol maleate is (S)-1-[(1,1-dimethylethyl)amino]-3-[[4-(4-morpholinyl)-1,2,5-thiadiazol-3-yl]oxy]-2-propanol (Z )-2-butenedioate (1:1) salt. Its empirical formula is C13H24N4O3S_C4H4O4. Its structual formula is:
Timolol maleate has a molecular weight of 432.50. It is a white, odorless, crystalline powder which is soluble in water, methanol, and alcohol.
Hydrochlorothiazide is 6-chloro-3,4-dihydro-2H-1,2,4-benzo-thiadiazine-7-sulfonamide 1,1-dioxide. Its empirical formula is C7H8ClN3O4S2. Its structual formula is:
Hydrochlorothiazide has a molecular weight of 297.73. It is a white, or practically white, crystalline powder which is slightly soluble in water, but freely soluble in sodium hydroxide solution.
TIMOLIDE (timolol maleate-hydrochlorothiazide) is supplied as tablets containing 10mg of timolol maleate and 25 mg of hydrochlorothiazide for oral administration. Inactive ingredients are cellulose, FD&C Blue 2, magnesium stearate, and starch.
What are the possible side effects of hydrochlorothiazide and timolol (Timolide 10-25)?
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Stop using this medication and call your doctor at once if you have any of these serious side effects:
- swelling, rapid weight gain, feeling short of breath, even with mild exertion;
- fast, slow, or uneven heartbeat;
- easy bruising or bleeding;
- sudden numbness or weakness on one side of the body, problems with vision or speech, chest pain, or pain in one or both...
What are the precautions when taking timolol maleate-hydrochlorothiazide (Timolide)?
Last reviewed on RxList: 1/28/2005
This monograph has been modified to include the generic and brand name in many instances.
Additional Timolide Information
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
Get tips on handling your hypertension.