"Dec. 18, 2012 -- People who can't get their high blood pressure down with drugs may be helped by a new procedure that deactivates overactive nerves in the kidneys, a small study shows.
The procedure is already available in Europe and "...
(Generic versions may still be available.)
TIMOLIDE* (Timolol Maleate-Hydrochlorothiazide) is for the treatment of hyper-tension. It combines the antihyper-tensive activity of two agents: a non-selective beta-adrenergic receptor blocking agent (timolol maleate) and a diuretic (hydrochlorothiazide).
Timolol maleate is (S)-1-[(1,1-dimethylethyl)amino]-3-[[4-(4-morpholinyl)-1,2,5-thiadiazol-3-yl]oxy]-2-propanol (Z )-2-butenedioate (1:1) salt. Its empirical formula is C13H24N4O3S_C4H4O4. Its structual formula is:
Timolol maleate has a molecular weight of 432.50. It is a white, odorless, crystalline powder which is soluble in water, methanol, and alcohol.
Hydrochlorothiazide is 6-chloro-3,4-dihydro-2H-1,2,4-benzo-thiadiazine-7-sulfonamide 1,1-dioxide. Its empirical formula is C7H8ClN3O4S2. Its structual formula is:
Hydrochlorothiazide has a molecular weight of 297.73. It is a white, or practically white, crystalline powder which is slightly soluble in water, but freely soluble in sodium hydroxide solution.
TIMOLIDE (timolol maleate-hydrochlorothiazide) is supplied as tablets containing 10mg of timolol maleate and 25 mg of hydrochlorothiazide for oral administration. Inactive ingredients are cellulose, FD&C Blue 2, magnesium stearate, and starch.
Last reviewed on RxList: 1/28/2005
This monograph has been modified to include the generic and brand name in many instances.
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