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Timoptic in Ocudose

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Timoptic in Ocudose

TIMOPTIC® 0.25% AND 0.5%
(Timolol Maleate) Ophthalmic Solution in OCUDOSE® (Dispenser)



Timolol maleate is a non-selective beta-adrenergic receptor blocking agent. Its chemical name is (-)-l-(tert-butylamino)-3-[(4-morpholino-l,2,5-thiadiazol-3-yl)oxy]-2-propanolmaleate (1:1) (salt). Timolol maleate possesses an asymmetric carbon atom in its structure and is provided as the levo-isomer. The optical rotation of timolol maleate is:

[α]   in l.0N HC1 (C = 5%) = -12.2° (-11.7° to -12.5°).
  405 nm  

Its molecular formula is C13H24N4O3S•C4H4O4 and its structural formula is:

Timoptic (Timolol Maleate) Structural Formula Illustration

Timolol maleate has a molecular weight of 432.50. It is a white, odorless, crystalline powder which is soluble in water, methanol, and alcohol. Timolol maleate is stable at room temperature.

Timolol maleate ophthalmic solution is supplied in two formulations: Ophthalmic Solution TIMOPTIC. (timolol maleate ophthalmic solution), which contains the preservative benzalkonium chloride; and Ophthalmic Solution TIMOPTIC (timolol maleate ophthalmic solution), the preservative-free formulation.

Preservative-free Ophthalmic Solution TIMOPTIC is supplied in OCUDOSE, a unit dose container, as a sterile, isotonic, buffered, aqueous solution of timolol maleate in two dosage strengths: Each mL of Preservative-free TIMOPTIC in OCUDOSE 0.25% contains 2.5 mg of timolol (3.4 mg of timolol maleate). The pH of the solution is approximately 7.0, and the osmolarity is 252-328 mOsm. Each mL of Preservative-free TIMOPTIC in OCUDOSE 0.5% contains 5 mg of timolol (6.8 mg of timolol maleate). Inactive ingredients: monobasic and dibasic sodium phosphate, sodium hydroxide to adjust pH, and water for injection.

What are the possible side effects of timolol ophthalmic?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using this medication and call your doctor at once if you have any of these serious side effects:

  • swelling or redness of your eyelids;
  • eye redness, discomfort, or sensitivity to light;
  • drainage, crusting, or oozing of your eyes or eyelids;
  • depressed mood, confusion, hallucinations, unusual thoughts or behavior;
  • wheezing, gasping, or other breathing problems;
  • swelling,...

Read All Potential Side Effects and See Pictures of Timoptic in Ocudose »

Last reviewed on RxList: 10/11/2011
This monograph has been modified to include the generic and brand name in many instances.

Report Problems to the Food and Drug Administration


You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

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