Tirosint (Levothyroxine Sodium Capsules) Drug Information: Description, User Reviews, Drug Side Effects, Interactions

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May 27, 2012

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Tirosint

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TIROSINT
(levothyroxine sodium)

WARNING

NOT FOR TREATMENT OF OBESITY OR FOR WEIGHT LOSS

Thyroid hormones, including TIROSINT, either alone or with other therapeutic agents, should not be used for the treatment of obesity or for weight loss.
In euthyroid patients, doses within the range of daily hormonal requirements are ineffective for weight reduction.
Larger doses may produce serious or even life threatening manifestations of toxicity, particularly when given in association with sympathomimetic amines such as those used for their anorectic effects [See ADVERSE REACTIONS, DRUG INTERACTIONS, and OVERDOSAGE].

DRUG DESCRIPTION

TIROSINT (levothyroxine sodium) is L-thyroxine. The orally administered gelatin capsules contain synthetic L-3,3',5,5'-tetraiodothyronine sodium salt [levothyroxine (T₄) sodium]. Synthetic T₄ is chemically identical to that produced in the human thyroid gland. Levothyroxine (T₄) sodium has an empirical formula of C₁₅H₁₀I₄NNaO₄ • x H₂O (where x = 5), molecular weight of 798.86 g/mol (anhydrous), and structural formula as shown:

TIROSINT (levothyroxine sodium) Structural Formula Illustration

The inactive ingredients in TIROSINT are gelatin, glycerin and water.

What are the precautions when taking levothyroxine sodium capsules (Tirosint)?

Before taking levothyroxine, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: increased thyroid hormones (thyrotoxicosis), decreased adrenal gland function, heart disease (such as coronary artery disease, irregular heartbeat), high blood pressure, diabetes.

Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

Current information shows that this drug may be used during pregnancy....

Read All Potential Precautions of Tirosint »

Last reviewed on RxList: 3/14/2012
This monograph has been modified to include the generic and brand name in many instances.