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Tirosint Side Effects Center
Medical Editor: John P. Cunha, DO, FACOEP
Tirosint (levothyroxine sodium) treats hypothyroidism (low thyroid hormone). It is also used to treat or prevent goiter (enlarged thyroid gland), which can be caused by hormone imbalances, radiation treatment, surgery, or cancer. Tirosint is a replacement for a hormone that is normally produced by your thyroid gland to regulate the body's energy and metabolism. This medication is available in generic form. Common side effects include hair loss, headache, sleep problems, nervous or irritable feeling, fever, sweating, changes in menstrual cycle, and appetite or weight changes.
Tirosint is taken in a single daily dose, ranging in strengths of 13 mcg to 150 mcg, preferably ½ to 1 hour before breakfast. Tirosint may interact with medications such as calcium carbonate (Caltrate, Citracal, Oystercal, and others), iron supplements, sucralfate (Carafate), sodium polystyrene sulfonate (Kayexalate, Kionex, and others), antacids containing aluminum (Maalox, Mylanta, Tums, and others), and cholesterol-lowering drugs cholestyramine (Questran) and colestipol (Colestid). Tell your doctor all medications or supplements you take. If you are pregnant or become pregnant, tell your doctor because your dose may need adjustment. This medication passes into breast milk but is unlikely to harm a nursing infant. Consult your doctor before breastfeeding.
Our Tirosint (levothyroxine sodium) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
What is Patient Information in Detail?
Easy-to-read and understand detailed drug information and pill images for the patient or caregiver from Cerner Multum.
Tirosint in Detail - Patient Information: Side Effects
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have a serious side effect such as:
- sleep problems (insomnia);
- feeling nervous or irritable;
- fever, hot flashes, sweating;
- pounding heartbeats or fluttering in your chest;
- changes in your menstrual periods; or
- appetite changes, weight changes.
Less serious side effects may include mild hair loss.
Read the entire detailed patient monograph for Tirosint (Levothyroxine Sodium Capsules) »
What is Prescribing information?
The FDA package insert formatted in easy-to-find categories for health professionals and clinicians.
Tirosint FDA Prescribing Information: Side Effects
Common adverse reactions with levothyroxine therapy are primarily those of hyperthyroidism due to therapeutic overdosage [See OVERDOSAGE]. They include the following:
- General: fatigue, increased appetite, weight loss, heat intolerance, fever, excessive sweating
- Central nervous system: headache, hyperactivity, nervousness, anxiety, irritability, emotional lability, insomnia
- Musculoskeletal: tremors, muscle weakness
- Cardiovascular: palpitations, tachycardia, arrhythmias, increased pulse and blood pressure, heart failure, angina, myocardial infarction, cardiac arrest
- Respiratory: dyspnea
- Gastrointestinal (GI): diarrhea, vomiting, abdominal cramps, elevations in liver function tests
- Dermatologic: hair loss, flushing
- Endocrine: decreased bone mineral density
- Reproductive: menstrual irregularities, impaired fertility
Adverse Reactions in Children
Pseudotumor cerebri and slipped capital femoral epiphysis have been reported in children receiving levothyroxine therapy. Overtreatment may result in craniosynostosis in infants and premature closure of the epiphyses in children with resultant compromised adult height. Seizures have been reported rarely with the institution of levothyroxine therapy.
Hypersensitivity reactions to inactive ingredients (in this product or other levothyroxine products) have occurred in patients treated with thyroid hormone products. These include urticaria, pruritus, skin rash, flushing, angioedema, various GI symptoms (abdominal pain, nausea, vomiting and diarrhea), fever, arthralgia, serum sickness and wheezing. Hypersensitivity to levothyroxine itself is not known to occur.
Read the entire FDA prescribing information for Tirosint (Levothyroxine Sodium Capsules) »
Additional Tirosint Information
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
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