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TNKase (tenecteplase) therapy in patients with acute myocardial infarction is contraindicated in the following situations because of an increased risk of bleeding (see WARNINGS):
- Active internal bleeding
- History of cerebrovascular accident
- Intracranial or intraspinal surgery or trauma within 2 months
- Intracranial neoplasm, arteriovenous malformation,or aneurysm
- Known bleeding diathesis
- Severe uncontrolled hypertension
Last reviewed on RxList: 11/6/2008
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