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TNKase (tenecteplase) therapy in patients with acute myocardial infarction is contraindicated in the following situations because of an increased risk of bleeding (see WARNINGS):

  • Active internal bleeding
  • History of cerebrovascular accident
  • Intracranial or intraspinal surgery or trauma within 2 months
  • Intracranial neoplasm, arteriovenous malformation,or aneurysm
  • Known bleeding diathesis
  • Severe uncontrolled hypertension
This monograph has been modified to include the generic and brand name in many instances.

Last reviewed on RxList: 11/6/2008


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