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Tobradex ST

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Tobradex ST

TOBRADEX® ST
(tobramycin / dexamethasone) Ophthalmic Suspension 0.3%/0.05%

DRUG DESCRIPTION

TOBRADEX® ST (tobramycin / dexamethasone ophthalmic suspension) 0.3%/0.05% is a sterile, isotonic, white, aqueous antibiotic and steroid suspension with a pH of approximately 5.7 and an osmolality of approximately 290 mOsm/kg.

The chemical name of tobramycin is O-3­amino-3-deoxy-α-D-glucopyranosyl-(1→4)­O-[2,6-diamino-2,3,6-trideoxy-α-D-ribo­hexopyranosyl-(1→6)]-2-deoxy- L­streptamine. It has a molecular formula of C18H37N5O9 and a molecular weight of 467.52. The chemical structure is:

Tobramycin Structural Formula Illustration

The chemical name of dexamethasone is 9­fluoro-11β,17,21-trihydroxy-16α­methylpregna-1,4-diene-3,20-dione. It has a molecular formula of C22H29FO5 and a molecular weight of 392.47. The chemical structure is:

Dexamethasone Structural Formula Illustration

Each mL of TOBRADEX ® ST contains: Actives: tobramycin 3 mg and dexamethasone 0.5 mg. Preservative: benzalkonium chloride 0.1 mg. Inactives: xanthan gum, tyloxapol, edetate disodium, sodium chloride, propylene glycol, sodium sulfate, hydrochloric acid and/or sodium hydroxide (to adjust pH) and purified water.

What are the possible side effects of tobramycin and dexamethasone ophthalmic (Tobradex)?

Serious side effects are not expected to occur with the use of this medication.

Some burning, stinging, irritation, itching, redness, blurred vision, eyelid itching, eyelid swelling, or sensitivity to light may occur.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at...

Read All Potential Side Effects and See Pictures of Tobradex ST »

What are the precautions when taking tobramycin / dexamethasone ophthalmic suspension 0.3%/0.05% (Tobradex ST)?

Before using tobramycin with dexamethasone, tell your doctor or pharmacist if you are allergic to either drug; or to other aminoglycoside antibiotics (e.g., gentamicin); or if you have any other allergies. This product may contain inactive ingredients (such as preservatives like benzalkonium chloride), which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: other eye problems (e.g., glaucoma).

Your vision may be temporarily unstable after applying this drug. Do not drive, use machinery, or do any activity that requires clear vision until you are sure you can perform such activities safely.

This medication should be used only when...

Read All Potential Precautions of Tobradex ST »

Last reviewed on RxList: 9/7/2010
This monograph has been modified to include the generic and brand name in many instances.

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Report Problems to the Food and Drug Administration

 

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.


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