Tobradex ST (Tobramycin / Dexamethasone Ophthalmic Suspension 0.3%/0.05%) Drug Information: Description, User Reviews, Drug Side Effects, Interactions

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February 10, 2012

Tobradex ST

Pink Eye »

What is "pink eye"?

Pink eye, or conjunctivitis, is redness and inflammation of the membranes (conjunctiva) covering the whites of the eyes and the membranes on the inner part of the eyelids. These membranes react to a wide range of bacteria, viruses, allergy-provoking agents, irritants, and toxic agents, as well as to underlying diseases within the body. Viral and bacterial forms of conjunctivitis are common in childhood, but they occur in adults as well. Pink eye can occur in people of any age. Overall, however, there are many causes of pink eye. These can be classified as either infectious or noninfectious. Pink eye does not cause any changes in vision.

What infections cause pink eye, what are infectious pink eye symptoms, and how are they treated?

Viral pink eye

The leading cause of a red, inflamed eye is virus infection. Adenoviruses are the type of virus that are most commonly responsible for the infection. ...

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Tobradex ST

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TOBRADEX® ST
(tobramycin / dexamethasone) Ophthalmic Suspension 0.3%/0.05%

DRUG DESCRIPTION

TOBRADEX® ST (tobramycin / dexamethasone ophthalmic suspension) 0.3%/0.05% is a sterile, isotonic, white, aqueous antibiotic and steroid suspension with a pH of approximately 5.7 and an osmolality of approximately 290 mOsm/kg.

The chemical name of tobramycin is O-3amino-3-deoxy-α-D-glucopyranosyl-(1→4)O-[2,6-diamino-2,3,6-trideoxy-α-D-ribohexopyranosyl-(1→6)]-2-deoxy- Lstreptamine. It has a molecular formula of C18H37N5O9 and a molecular weight of 467.52. The chemical structure is:

Tobramycin Structural Formula Illustration

The chemical name of dexamethasone is 9fluoro-11β,17,21-trihydroxy-16αmethylpregna-1,4-diene-3,20-dione. It has a molecular formula of C22H29FO5 and a molecular weight of 392.47. The chemical structure is:

Dexamethasone Structural Formula Illustration

Each mL of TOBRADEX ® ST contains: Actives: tobramycin 3 mg and dexamethasone 0.5 mg. Preservative: benzalkonium chloride 0.1 mg. Inactives: xanthan gum, tyloxapol, edetate disodium, sodium chloride, propylene glycol, sodium sulfate, hydrochloric acid and/or sodium hydroxide (to adjust pH) and purified water.

What are the precautions when taking tobramycin / dexamethasone ophthalmic suspension 0.3%/0.05% (Tobradex ST)?

Before using tobramycin with dexamethasone, tell your doctor or pharmacist if you are allergic to either drug; or to other aminoglycoside antibiotics (e.g., gentamicin); or if you have any other allergies. This product may contain inactive ingredients (such as preservatives like benzalkonium chloride), which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: other eye problems (e.g., glaucoma).

Your vision may be temporarily unstable after applying this drug. Do not drive, use machinery, or do any activity that requires clear vision until you are sure you can perform such activities safely.

This medication should be used only when...

Read All Potential Precautions of Tobradex ST »

Last reviewed on RxList: 9/7/2010
This monograph has been modified to include the generic and brand name in many instances.