Tobradex ST (Tobramycin / Dexamethasone Ophthalmic Suspension 0.3%/0.05%) Patient Information: Side Effects and Drug Images at RxList

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May 27, 2012

Tobradex ST

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What is the structure of the eye?

The eyes are complex sensory organs. About 85% of the total sensory input to our brains originates from our sense of sight, while the other 15% comes from the other four senses of hearing, smell, touch, and taste. The eyes are designed to optimize vision under conditions of varying light. Their location, on the outside of the face, makes them susceptible to trauma, environmental chemicals and particles, and infectious agents. The eyelids and the position of the eye within the bony orbital cavity are the major protective mechanism for the eye.

The eye itself has the shape of a sphere measuring about 1 inch in diameter. It consists of a clear, transparent dome at the front (the cornea) that is surrounded by the white of the eyeball (the sclera). The iris of the eye is the circular, colored portion within the eye, and behind the cornea, and the pupil is the central opening within the iris. Behind the iris and pupil is the e...

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TOBRADEX® ST
(tobramycin / dexamethasone) Ophthalmic Suspension 0.3%/0.05%

DRUG DESCRIPTION

TOBRADEX® ST (tobramycin / dexamethasone ophthalmic suspension) 0.3%/0.05% is a sterile, isotonic, white, aqueous antibiotic and steroid suspension with a pH of approximately 5.7 and an osmolality of approximately 290 mOsm/kg.

The chemical name of tobramycin is O-3amino-3-deoxy-α-D-glucopyranosyl-(1→4)O-[2,6-diamino-2,3,6-trideoxy-α-D-ribohexopyranosyl-(1→6)]-2-deoxy- Lstreptamine. It has a molecular formula of C18H37N5O9 and a molecular weight of 467.52. The chemical structure is:

Tobramycin Structural Formula Illustration

The chemical name of dexamethasone is 9fluoro-11β,17,21-trihydroxy-16αmethylpregna-1,4-diene-3,20-dione. It has a molecular formula of C22H29FO5 and a molecular weight of 392.47. The chemical structure is:

Dexamethasone Structural Formula Illustration

Each mL of TOBRADEX ® ST contains: Actives: tobramycin 3 mg and dexamethasone 0.5 mg. Preservative: benzalkonium chloride 0.1 mg. Inactives: xanthan gum, tyloxapol, edetate disodium, sodium chloride, propylene glycol, sodium sulfate, hydrochloric acid and/or sodium hydroxide (to adjust pH) and purified water.

Last reviewed on RxList: 9/7/2010
This monograph has been modified to include the generic and brand name in many instances.