Tobrex (Tobramycin Ophthalmic Ointment) Drug Information: Description, User Reviews, Drug Side Effects, Interactions

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February 9, 2012

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Tobrex

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TOBREX
(tobramycin) Ophthalmic Ointment

DRUG DESCRIPTION

TOBREX® (tobramycin ophthalmic ointment) 0.3% is a sterile topical ophthalmic antibiotic formulation prepared specifically for topical therapy of external ophthalmic infections.

Each gram of TOBREX (tobramycin ophthalmic ointment) 0.3% contains: Active: tobramycin 0.3% (3 mg). Preservative: chlorobutanol 0.5%. Inactives: mineral oil, white petrolatum.

Tobramycin is a water-soluble aminoglycoside antibiotic active against a wide variety of gram-negative and gram-positive ophthalmic pathogens.

The chemical structure of tobramycin is:

TOBREX (tobramycin) Structural Formula Illustration

Molecular formula: C₁₈H₃₇N₅O₉

Molecular weight: 467.52

Chemical name: 0-{3-amino-3-deoxy-α-D-gluco-pyranosyl-(1#4) }-0-{2,6-diamino-2,3,6-trideoxy-α-D-ribohexo-pyranosyl-(1#6) }-2-deoxystreptamine.

What are the possible side effects of tobramycin ophthalmic (Aktob, Tobralcon, Tobrasol, Tobrex)?

Serious side effects are not expected with this medication.

Commonly, some eye burning, stinging, irritation, itching, redness, blurred vision, eyelid itching, eyelid swelling, or sensitivity to light may occur.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at...

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What are the precautions when taking tobramycin ophthalmic ointment (Tobrex)?

Before using tobramycin, tell your doctor or pharmacist if you are allergic to it; or to other aminoglycosides (e.g., gentamicin); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: other eye problems.

This drug may cause temporary blurred or unstable vision after you apply it. Do not drive, use machinery, or do any activity that requires clear vision until you are sure you can perform such activities safely.

This medication should be used only when clearly needed during pregnancy. Discuss the risks and benefits with your doctor.

It is...

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Last reviewed on RxList: 3/26/2009
This monograph has been modified to include the generic and brand name in many instances.