Tofranil (Imipramine) Drug Center: Guide to Drug Information for Professionals, Patients and Caregivers at RxList

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May 27, 2012

Tofranil

Antidepressants »

What are antidepressants and how do they work?

Antidepressants are a class of drugs that reduce symptoms of depressive disorders by correcting chemical imbalances of neurotransmitters in the brain. Chemical imbalances may be responsible for changes in mood and behavior.

Neurotransmitters are vital, as they are the communication link between nerve cells in the brain. Neurotransmitters reside within vesicles found in nerve cells, which are released by one nerve and taken up by other nerves. Neurotransmitters not taken up by other nerves are taken up by the same nerves that released them. This process is called "reuptake." The prevalent neurotransmitters in the brain specific to depression are serotonin, dopamine and norepinephrine (also called noradrenaline).

In general, antidepressants work by inhibiting the reuptake of specific neurotransmitters, hence increasing their levels around the nerves within the brain, such...

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Tofranil

Understanding Depression Slideshow

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Benefits of Treating Depression

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Tofranil Drug Center

Medical Editor: John P. Cunha, DO, FACOEP

Prescribing Information

For Patients

Tofranil (imipramine hydrochloride) is used to treat symptoms of depression. It is a tricyclic antidepressant. This medication is available in generic form. Common side effects include dry mouth, blurred vision, headache, drowsiness, dizziness, constipation, nausea, vomiting, loss of appetite, diarrhea, stomach cramps, weight gain/loss, and increased sweating. You may have suicidal thoughts, especially if you are younger than 24 years old. Tell your doctor if this occurs.

For outpatient adults, the initial dose of Tofranil is 75 mg/day, increased to 150 mg/day. Dosages over 200 mg/day are not recommended. Dose may vary for adolescent, geriatric, childhood, or hospitalized patients. Tofranil may interact with SSRI antidepressants, cimetidine, clonidine, guanethidine, methylphenidate, or heart rhythm medications. Many other medications can interact with Tofranil. Tell your doctor all medications you use. Tofranil should be used only when prescribed during pregnancy. Infants born to mothers who have taken similar medications during pregnancy may have trouble urinating, prolonged sleepiness, shaking, and seizures. Consult your doctor. This medication passes into breast milk and may have undesirable effects on a nursing infant. Consult your doctor before breast-feeding.

Our Tofranil (imipramine hydrochloride) Drug Center provides a comprehensive view of available drug information as well as related drugs, user reviews, supplements, and diseases and conditions articles.

What is Prescribing information?

The FDA package insert formatted in easy-to-find categories for health professionals and clinicians.

Tofranil Prescribing Information: Indications & Dosage

Tofranil® (imipramine hydrochloride) Structural Formula Illustration

Depression - For the relief of symptoms of depression. Endogenous depression is more likely to be alleviated than other depressive states. One to three weeks of treatment may be needed before optimal therapeutic effects are evident.

Childhood Enuresis - May be useful as temporary adjunctive therapy in reducing enuresis in children aged 6 years and older, after possible organic causes have been excluded by appropriate tests. In patients having daytime symptoms of frequency and urgency, examination should include voiding cystourethrogr...

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What is Tofranil Prescribing Information?

Drug Description - Indications & Dosage - Side Effects & Drug Interactions - Warnings & Precautions - Contraindications - Medication Guide and More

What is Patient information?

Easy-to-read and understand detailed drug information and pill images for the patient or caregiver from Cerner Multum.

Tofranil Patient Information: Side Effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have any new or worsening symptoms such as: mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or have thoughts about suicide or hurting yourself.

Call your doctor at once if you have any of these serious side effects:

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What is Tofranil Patient Information?

Possible Side Effects - Images - What Is - How Should I Take It - What If I Miss a Dose - What Should I Avoid and More

What is Consumer information?

A concise overview of the drug for the patient or caregiver from First DataBank.

Tofranil Consumer Information: Uses

This medication is used to treat depression. It is also used with other therapies for the treatment of nighttime bed-wetting (enuresis) in children. Using this medication to treat depression may improve your mood, sleep, appetite, and energy level and may help restore your interest in daily living. Imipramine can help your child control nighttime bed-wetting.

Imipramine belongs to a class of medications called tricyclic antidepressants. It works by restoring the balance of certain natural substances (neurotransmitters such as norepinephrine) in the brain. For bed-wetting, this medication ma...

Read the complete consumer information for Tofranil »