"With the possible exception of fluoxetine (multiple brands), the vast majority of antidepressants are ineffective, and some may even be unsafe, for use in children and teens with major depressive disorder (MDD), new research shows.
Tofranil-PM Patient Information including If I Miss a Dose
In this Article
- What is imipramine (Tofranil-PM)?
- What are the possible side effects of imipramine (Tofranil-PM)?
- What is the most important information I should know about imipramine (Tofranil-PM)?
- What should I discuss with my healthcare provider before taking imipramine (Tofranil-PM)?
- How should I take imipramine (Tofranil-PM)?
- What happens if I miss a dose (Tofranil-PM)?
- What happens if I overdose (Tofranil-PM)?
- What should I avoid while taking imipramine (Tofranil-PM)?
- What other drugs will affect imipramine (Tofranil-PM)?
- Where can I get more information?
What happens if I miss a dose (Tofranil-PM)?
Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.
What happens if I overdose (Tofranil-PM)?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of imipramine can be fatal.
What should I avoid while taking imipramine (Tofranil-PM)?
Avoid drinking alcohol. It can cause dangerous side effects when taken together with imipramine.
Grapefruit and grapefruit juice may interact with imipramine. Discuss the use of grapefruit products with your doctor before increasing or decreasing the amount of grapefruit products in your diet.
Imipramine can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert.
Avoid exposure to sunlight or tanning beds. Imipramine can make you sunburn more easily. Wear protective clothing and use sunscreen (SPF 30 or higher) when you are outdoors.
What other drugs will affect imipramine (Tofranil-PM)?
Taking imipramine with other drugs that make you sleepy or slow your breathing can increase these effects. Ask your doctor before taking imipramine with a sleeping pill, narcotic pain medicine, muscle relaxer, or medicine for anxiety, depression, or seizures.
Before taking imipramine, tell your doctor if you have used an "SSRI" antidepressant in the past 5 weeks, such as citalopram, escitalopram, fluoxetine, fluvoxamine, paroxetine, or sertraline.
You must wait at least 5 weeks after stopping fluoxetine (Prozac) before you can take imipramine.
Many drugs can interact with imipramine. Not all possible interactions are listed here. Tell your doctor about all your medications and any you start or stop using during treatment with imipramine, especially:
- methylphenidate, Ritalin;
- phenobarbital and other barbiturates;
- St. John's wort;
- any other anti-depressant, or medication to treat mental illness;
- bladder or urinary medicines such as darifenacin, tolterodine, solifenacin;
- bronchodilators such as ipratropium or tiotropium;
- cold or allergy medicine that contains an antihistamine;
- the heart rhythm medications flecainide, propafenone, or quinidine;
- medication for Parkinson's disease; or
- medication to treat excess stomach acid, stomach ulcer, motion sickness, or irritable bowel syndrome.
This list is not complete and many other drugs can interact with imipramine. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Give a list of all your medicines to any healthcare provider who treats you.
Where can I get more information?
Your pharmacist can provide more information about imipramine.
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
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Additional Tofranil-PM Information
- Tofranil-PM Drug Interactions Center: imipramine pamoate oral
- Tofranil-PM Side Effects Center
- Tofranil-PM Overview including Precautions
- Tofranil-PM FDA Approved Prescribing Information including Dosage
Tofranil-PM - User Reviews
Tofranil-PM User Reviews
Now you can gain knowledge and insight about a drug treatment with Patient Discussions.
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
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