"What are tricyclic antidepressants, and how do they work?
Tricyclic antidepressants (TCAs) are a class of antidepressant medications that share a similar chemical structure and biological effects. Scientists believe that patients with d"...
Tofranil-PM Side Effects Center
Medical Editor: John P. Cunha, DO, FACOEP
- dry mouth
- blurred vision
- loss of appetite
- stomach cramps
- weight gain/loss
- increased sweating
- tingly feeling
- lack of coordination
- blurred vision
- ringing in your ears
- breast swelling (in men or women)
- decreased sex drive
- impotence, or
- difficulty having an orgasm.
The starting dose of Tofranil-PM is 75 mg/day. Dosage may be increased to 150 mg/day which is the dose level at which optimum response is usually obtained. Tofranil-PM may interact with SSRI antidepressants cimetidine clonidine guanethidine methylphenidate or heart rhythm medications. Many other medicines can interact with Tofranil-PM. Tell your doctor all medications and supplements you use. Tofranil-PM should be used only when prescribed during pregnancy. Infants born to mothers who have taken similar medications during pregnancy may have symptoms such as trouble urinating prolonged sleepiness shaking and seizures. Discuss the risks and benefits with your doctor. This medication passes into breast milk and may have undesirable effects on a nursing infant. Consult your doctor before breastfeeding.
Our Tofranil-PM (imipramine pamoate) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.
What is Patient Information in Detail?
Easy-to-read and understand detailed drug information and pill images for the patient or caregiver from Cerner Multum.
Tofranil-PM in Detail - Patient Information: Side Effects
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Report any new or worsening symptoms to your doctor, such as: mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or have thoughts about suicide or hurting yourself.
Call your doctor at once if you have:
- feeling like you might pass out;
- new or worsening chest pain, pounding heartbeats or fluttering in your chest;
- sudden numbness or weakness, problems with vision, speech, or balance;
- fever, sore throat;
- easy bruising, unusual bleeding (nose, mouth, vagina, or rectum), purple or red pinpoint spots under your skin;
- confusion, hallucinations, unusual thoughts or behavior;
- painful or difficult urination;
- seizure (convulsions); or
- jaundice (yellowing of the skin or eyes).
Other common side effects may include:
- tingly feeling, weakness, lack of coordination;
- dry mouth, nausea, vomiting, constipation, diarrhea;
- blurred vision, ringing in your ears;
- breast swelling (in men or women); or
- decreased sex drive, impotence, or difficulty having an orgasm.
Read the entire detailed patient monograph for Tofranil-PM (Imipramine Pamoate)
What is Patient Information Overview?
A concise overview of the drug for the patient or caregiver from First DataBank.
Tofranil-PM Overview - Patient Information: Side Effects
Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.
Tell your doctor immediately if any of these unlikely but serious side effects occur: mental/mood changes (e.g., confusion, depression, memory problems), enlarged/painful breasts, unusual breast milk production, irregular/painful menstrual periods, muscle stiffness, restlessness, ringing in the ears, sexual problems (e.g., decreased sexual ability, changes in desire), shakiness (tremors), numbness/tingling of the hands/feet, pain/redness/swelling of arms or legs, trouble urinating.
Tell your doctor immediately if any of these rare but very serious side effects occur: easy bruising/bleeding, signs of infection (e.g., fever, persistent sore throat), severe stomach/abdominal pain, dark urine, yellowing of eyes/skin.
This medication may increase serotonin and rarely cause a very serious condition called serotonin syndrome/toxicity. The risk increases if you are also taking other drugs that increase serotonin, so tell your doctor or pharmacist of all the drugs you take (see Drug Interactions section). Get medical help right away if you develop some of the following symptoms: fast heartbeat, hallucinations, loss of coordination, severe dizziness, severe nausea/vomiting/diarrhea, twitching muscles, unexplained fever, unusual agitation/restlessness.
Get medical help right away if you have any very serious side effects, including: chest pain, slow/fast/irregular heartbeat, fainting, seizures, slurred speech, weakness on one side of the body, eye pain/swelling/redness, vision changes (such as seeing rainbows around lights at night).
A very serious allergic reaction to this drug is unlikely, but seek immediate medical attention if it occurs. Symptoms of a serious allergic reaction include: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.
This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.
In the US -
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.
Read the entire patient information overview for Tofranil-PM (Imipramine Pamoate)
What is Prescribing information?
The FDA package insert formatted in easy-to-find categories for health professionals and clinicians.
Tofranil-PM FDA Prescribing Information: Side Effects
Note: Although the listing which follows includes a few adverse reactions which have not been reported with this specific drug, the pharmacological similarities among the tricyclic antidepressant drugs require that each of the reactions be considered when imipramine is administered.
Dry mouth, and, rarely, associated sublingual adenitis; blurred vision, disturbances of accommodation, mydriasis; constipation, paralytic ileus; urinary retention, delayed micturition, dilation of the urinary tract.
Nausea and vomiting, anorexia, epigastric distress, diarrhea; peculiar taste, stomatitis, abdominal cramps, black tongue.
Gynecomastia in the male; breast enlargement and galactorrhea in the female; increased or decreased libido, impotence; testicular swelling; elevation or depression of blood sugar levels; inappropriate antidiuretic hormone (ADH) secretion syndrome.
Jaundice (simulating obstructive); altered liver function; weight gain or loss; perspiration; flushing; urinary frequency; drowsiness, dizziness, weakness and fatigue; headache; parotid swelling; alopecia; proneness to falling.
Though not indicative of addiction, abrupt cessation of treatment after prolonged therapy may produce nausea, headache and malaise.
Read the entire FDA prescribing information for Tofranil-PM (Imipramine Pamoate)
Additional Tofranil-PM Information
Tofranil-PM - User Reviews
Tofranil-PM User Reviews
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