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Tofranil-PM

Last reviewed on RxList: 1/18/2017
Tofranil-PM Side Effects Center

Last reviewed on RxList 3/21/2016

Tofranil-PM (imipramine pamoate) is a tricyclic antidepressant used to treat symptoms of depression. Tofranil-PM is available in generic form. Common side effects of Tofranil-PM include:

Tell your doctor if you have worsening depression or suicidal thoughts while taking Tofranil-PM.

The starting dose of Tofranil-PM is 75 mg/day. Dosage may be increased to 150 mg/day which is the dose level at which optimum response is usually obtained. Tofranil-PM may interact with SSRI antidepressants cimetidine clonidine guanethidine methylphenidate or heart rhythm medications. Many other medicines can interact with Tofranil-PM. Tell your doctor all medications and supplements you use. Tofranil-PM should be used only when prescribed during pregnancy. Infants born to mothers who have taken similar medications during pregnancy may have symptoms such as trouble urinating prolonged sleepiness shaking and seizures. Discuss the risks and benefits with your doctor. This medication passes into breast milk and may have undesirable effects on a nursing infant. Consult your doctor before breastfeeding.

Our Tofranil-PM (imipramine pamoate) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Tofranil-PM Consumer Information

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Report any new or worsening symptoms to your doctor, such as: mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or have thoughts about suicide or hurting yourself.

Call your doctor at once if you have:

  • feeling like you might pass out;
  • new or worsening chest pain, pounding heartbeats or fluttering in your chest;
  • sudden numbness or weakness, problems with vision, speech, or balance;
  • fever, sore throat;
  • easy bruising, unusual bleeding (nose, mouth, vagina, or rectum), purple or red pinpoint spots under your skin;
  • confusion, hallucinations, unusual thoughts or behavior;
  • painful or difficult urination;
  • seizure (convulsions); or
  • jaundice (yellowing of the skin or eyes).

Other common side effects may include:

  • tingly feeling, weakness, lack of coordination;
  • dry mouth, nausea, vomiting, constipation, diarrhea;
  • blurred vision, ringing in your ears;
  • breast swelling (in men or women); or
  • decreased sex drive, impotence, or difficulty having an orgasm.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Tofranil-PM (Imipramine Pamoate)

Tofranil-PM Professional Information

SIDE EFFECTS

Note: Although the listing which follows includes a few adverse reactions which have not been reported with this specific drug, the pharmacological similarities among the tricyclic antidepressant drugs require that each of the reactions be considered when imipramine is administered.

Cardiovascular

Orthostatic hypotension, hypertension, tachycardia, palpitation, myocardial infarction, arrhythmias, heart block, ECG changes, precipitation of congestive heart failure, stroke.

Psychiatric

Confusional states (especially in the elderly) with hallucinations, disorientation, delusions; anxiety, restlessness, agitation; insomnia and nightmares; hypomania; exacerbation of psychosis.

Neurological

Numbness, tingling, paresthesias of extremities; incoordination, ataxia, tremors; peripheral neuropathy; extrapyramidal symptoms; seizures, alterations in EEG patterns; tinnitus.

Anticholinergic

Dry mouth, and, rarely, associated sublingual adenitis; blurred vision, disturbances of accommodation, mydriasis; constipation, paralytic ileus; urinary retention, delayed micturition, dilation of the urinary tract.

Allergic

Skin rash, petechiae, urticaria, itching, photosensitization; edema (general or of face and tongue); drug fever; cross-sensitivity with desipramine.

Hematologic

Bone marrow depression including agranulocytosis; eosinophilia; purpura; thrombocytopenia.

Gastrointestinal

Nausea and vomiting, anorexia, epigastric distress, diarrhea; peculiar taste, stomatitis, abdominal cramps, black tongue.

Endocrine

Gynecomastia in the male; breast enlargement and galactorrhea in the female; increased or decreased libido, impotence; testicular swelling; elevation or depression of blood sugar levels; inappropriate antidiuretic hormone (ADH) secretion syndrome.

Other

Jaundice (simulating obstructive); altered liver function; weight gain or loss; perspiration; flushing; urinary frequency; drowsiness, dizziness, weakness and fatigue; headache; parotid swelling; alopecia; proneness to falling.

Withdrawal Symptoms

Though not indicative of addiction, abrupt cessation of treatment after prolonged therapy may produce nausea, headache and malaise.

Read the entire FDA prescribing information for Tofranil-PM (Imipramine Pamoate)

Related Resources for Tofranil-PM

Read the Tofranil-PM User Reviews »

© Tofranil-PM Patient Information is supplied by Cerner Multum, Inc. and Tofranil-PM Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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