"The U.S. Food and Drug Administration today approved Dotarem (gadoterate meglumine) for use in magnetic resonance imaging (MRI) of the brain, spine and associated tissues of patients ages 2 years and older.
Dotarem is a gadolinium-based"...
(Generic versions may still be available.)
The initial and most important signs and symptoms of. overdosage would be expected to be related to the central nervous system. Other adverse reactions, such as gastrointestinal disturbances, may follow. (See ADVERSE REACTIONS.)
Should convulsions or cardiopulmonary depression or arrest develop, the patency of the airway and adequacy of ventilation must be assured immediately. Should convulsions persist, despite ventilatory therapy with oxygen, small increments of anticonvulsive agents may be given intravenously. Examples of such agents include a benzodiazepine (e.g., diazepam), an ultrashort-acting barbiturate (e.g., thiopental or thiamylal), or a short-acting barbiturate (e.g., pentobarbital or secobarbital).
The oral LD50 of tocainide was calculated to be about 800 mg/kg in mice, 1000 mg/kg in rats, and 230 mg/kg in guinea pigs; deaths were usually preceded by convulsions.
Last reviewed on RxList: 12/8/2004
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