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Mitral valve prolapse (also known as "click murmur syndrome" and "Barlow's syndrome") is the most common heart valve abnormality, affecting five to ten percent of the world population. A normal mitral valve consists of two thin leaflets, located between the left atrium and the left ventricle of the heart. Mitral valve leaflets, shaped like parachutes, are attached to the inner wall of the left ventricle by a series of strings called "chordae." When the ventricles contract, the mitral valve leaflets close snugly and prevent the backflow of blood from the left ventricle into the left atrium. When the ventricles relax, the valves open to allow oxygenated blood from the lungs to fill the left ventricle.
In patients with mitral valve prolapse, the mitral apparatus (valve leaflets and chordae) becomes affected by a process called myxomatous degeneration. In myxomatous degeneration, the structural protein collagen forms abnormally and caus...
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Pharmacy Editor: Eni Williams, PharmD, PhD
Toprol XL (metoprolol) is a medication that belongs to the drug class called beta blockers. Toprol XL is available as a generic drug, and is prescribed for treating high blood pressure, heart pain, abnormal rhythms of the heart, and some neurologic conditions. Common side effects of Toprol XL include abdominal cramps, diarrhea, constipation, fatigue, insomnia, nausea, depression, impotence, lightheadedness, slow heart rate, low blood pressure, cold extremities, and shortness, of breath or wheezing.
Toprol XL usual adult dose is 100-450 mg daily in single or divided doses. Drug interactions include calcium channel blockers (for example, verapamil [Isoptin]) and digoxin (Lanoxin). There are no adequate studies of Toprol XL in pregnant women and is secreted in human breast milk.
Our Toprol XL Drug Center provides a comprehensive view of available drug information as well as related drugs, user reviews, supplements and disease and conditions articles.
What is Prescribing information?
The FDA package insert formatted in easy-to-find categories for health professionals and clinicians.
TOPROL-XL (metoprolol succinate) is indicated for the treatment of hypertension. It may be used alone or in combination with other antihypertensive agents [see DOSAGE AND ADMINISTRATION].
TOPROL-XL (metoprolol succinate) is indicated in the long-term treatment of angina pectoris, to reduce angina attacks and to improve exercise tolerance.
TOPROL-XL (metoprolol succinate) is indicated for the treatment of stable, symptomatic (NYHA Class II or III) heart failure of ischemic, hypertensive, or ca...
Read the complete drug monograph for Toprol XL »
Drug Description - Indications & Dosage - Side Effects & Drug Interactions - Warnings & Precautions - Contraindications - Medication Guide and More
What is Patient information?
Easy-to-read and understand detailed drug information and pill images for the patient or caregiver from Cerner Multum.
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have any of these serious side effects:
Read the complete patient information for Toprol XL »
Possible Side Effects - Images - What Is - How Should I Take It - What If I Miss a Dose - What Should I Avoid and More
What is Consumer information?
A concise overview of the drug for the patient or caregiver from First DataBank.
This drug works by blocking the action of certain natural chemicals in your body (such as epinephrine) that affect the heart and blood vessels. This lowers heart rate, blood pressure, and strain on the heart.
OTHER USES: This section contains uses of this drug that are not listed in the approved US professional labeling for the drug but that may be pres...
Read the complete consumer information for Toprol XL »
Warnings - Uses - How to Use - Side Effects - Precautions - Drug Interactions and More
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
Get tips on handling your hypertension.