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MEDICATION GUIDE FOR NONSTEROIDAL ANTI-INFLAMMATORY DRUGS (NSAIDS)
(See the end of this Medication Guide for a list of prescription NSAID medicines.)
What is the most important information I should know about medicines called Nonsteroidal Anti-Inflammatory Drugs (NSAIDs)?
NSAID medicines may increase the chance of a heart attack or stroke that can lead to death. This chance increases:
- with longer use of NSAID medicines
- in people who have heart disease
NSAID medicines should never be used right before or after a heart surgery called a “coronary artery bypass graft (CABG).”
NSAID medicines can cause ulcers and bleeding in the stomach and intestines at any time during treatment. Ulcers and bleeding:
- can happen without warning symptoms
- may cause death
The chance of a person getting an ulcer or bleeding increases with:
- taking medicines called “corticosteroids” and “anticoagulants”
- longer use
- drinking alcohol
- older age
- having poor health
NSAID medicines should only be used:
- exactly as prescribed
- at the lowest dose possible for your treatment
- for the shortest time needed
What are Nonsteroidal Anti-Inflammatory Drugs (NSAIDs)?
NSAID medicines are used to treat pain and redness, swelling, and heat (inflammation) from medical conditions such as:
- different types of arthritis
- menstrual cramps and other types of short-term pain
Who should not take a Nonsteroidal Anti-Inflammatory Drug (NSAID)?
Do not take an NSAID medicine:
- if you had an asthma attack, hives, or other allergic reaction with aspirin or any other NSAID medicine
- for pain right before or after heart bypass surgery
Tell your healthcare provider:
- about all of your medical conditions.
- about all of the medicines you take. NSAIDs and some other medicines can interact with each other and cause serious side effects. Keep a list of your medicines to show to your healthcare provider and pharmacist.
- if you are pregnant. NSAID medicines should not be used by pregnant women late in their pregnancy.
- if you are breastfeeding. Talk to your doctor.
What are the possible side effects of Nonsteroidal Anti-Inflammatory Drugs (NSAIDs)?
Serious side effects include:
Other side effects include:
Get emergency help right away if you have any of the following symptoms:
- shortness of breath or trouble breathing
- chest pain
- weakness in one part or side of your body
- slurred speech
- swelling of the face or throat
Stop your NSAID medicine and call your healthcare provider right away if you have any of the following symptoms:
- more tired or weaker than usual
- your skin or eyes look yellow
- stomach pain
- flu-like symptoms
- vomit blood
- there is blood in your bowel movement or it is black and sticky like tar
- unusual weight gain
- skin rash or blisters with fever
- swelling of the arms and legs, hands and feet
These are not all the side effects with NSAID medicines. Talk to your healthcare provider or pharmacist for more information about NSAID medicines.
Other information about Nonsteroidal Anti-Inflammatory Drugs (NSAIDs):
- Aspirin is an NSAID medicine but it does not increase the chance of a heart attack. Aspirin can cause bleeding in the brain, stomach, and intestines. Aspirin can also cause ulcers in the stomach and intestines.
- Some of these NSAID medicines are sold in lower doses without a prescription (over-the-counter). Talk to your healthcare provider before using over-the-counter NSAIDs for more than 10 days.
NSAID medicines that need a prescription:
|Diclofenac||Cataflam, Voltaren, Arthrotec (combined with misoprostol)|
|Etodolac||Lodine, Lodine XL|
|Fenoprofen||Nalfon, Nalfon 200|
|Ibuprofen||Motrin, Tab-Profen, Vicoprofen* (combined with hydrocodone), Combunox (combined with oxycodone)|
|Indomethacin||Indocin, Indocin SR, Indo-Lemmon, Indomethagan|
|Naproxen||Naprosyn, Anaprox, Anaprox DS, EC-Naproxyn, Naprelan, Naprapac (copackaged with lansoprazole)|
|Tolmetin||Tolectin, Tolectin DS, Tolectin 600|
*Vicoprofen contains the same dose of ibuprofen as over-the-counter (OTC) NSAIDs, and is usually used for less than 10 days to treat pain. The OTC NSAID label warns that long term continuous use may increase the risk of heart attack or stroke.
This Medication Guide has been approved by the U.S. Food and
Drug Administration. Date created: June 15, 2005.Celebrex is a registered trademark
of G.D. Searle LLC. Cataflam, Voltaren are registered trademarks of Novartis
Corporation. Arthrotec (combined with misoprostol) is a registered trademark
of G.D. Searle LLC. Dolobid is a registered trademark of Merck & Co. Inc.
Lodine, Lodine XL are registered trademarks of Wyeth. Nalfon, Nalfon 200 are
registered trademarks of Pedinol Pharmacal Inc. Ansaid is a registered trademark
of Pharmacia & Upjohn Company LLC. Motrin is a registered trademark of Johnson
& Johnson. Tab-Profen is a registered trademark of L. Perrigo Company. Vicoprofen
(combined with hydrocodone) is a registered trademark of BASF K & F Corporation.
Combunox (combined with oxycodone) is a registered trademark of Forest Laboratories, Inc.Indocin, Indocin SR are registered trademarks of Merck & Co. Inc. Oruvail is a registered trademark of Imperial Bank, As Agent (formerly registered to Aventis Pharma S.A.). Toradol (ketorolac tromethamine) is a registered trademark of Hoffmann-La Roche Inc. Ponstel is a registered trademark of Lasalle National Bank Association.
Mobic is a registered trademark of Boehringer Ingelheim Pharma GMBG & Co. Kg. Relafen is a registered trademark of SmithKline Beecham Corporation. Naprosyn, EC-Naprosyn, Anaprox, Anaprox DS are registered trademarks of Syntex Pharmaceuticals International Ltd. Naprelan is a registered trademark of Elan Corporation PLC. Naprapac (copackaged with lansoprazole) is a registered trademark of Syntex Pharmaceuticals International Ltd. Daypro is a registered trademark of G.D. Searle LLC. Feldene is a registered trademark of Pfizer. Clinoril is a registered trademark of Merck & Co. Inc. Tolectin, Tolectin DS, Tolectin 600 are registered trademarks of Johnson & Johnson Corporation.
Last reviewed on RxList: 1/11/2017
This monograph has been modified to include the generic and brand name in many instances.
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