home > drugs a-z list > torisel (temsirolimus injection) drug center > torisel (temsirolimus injection) drug - medication guide and patient information

• Allergic (Hypersensitivity) Reactions
  Patients should be informed of the possibility of serious allergic reactions, including anaphylaxis, despite premedication with antihistamines, and to immediately report any facial swelling or difficulty breathing [see WARNINGS AND PRECAUTIONS].
• Increased Blood Glucose Levels
  Patients are likely to experience increased blood glucose levels while taking TORISEL (temsirolimus injection) . This may result in the need for initiation of, or increase in the dose of, insulin and/or hypoglycemic agents. Patients should be directed to report any excessive thirst or frequency of urination to their physician [see WARNINGS AND PRECAUTIONS].
• Infections
  Patients should be informed that they may be more susceptible to infections while being treated with TORISEL [see WARNINGS AND PRECAUTIONS].
• Interstitial Lung Disease
  Patients should be warned of the possibility of developing interstitial lung disease, a chronic inflammation of the lungs, which may rarely result in death [see WARNINGS AND PRECAUTIONS]. Patients should be directed to report promptly any new or worsening respiratory symptoms to their physician.
• Increased Blood Triglycerides and/or Cholesterol
  Patients are likely to experience elevated triglycerides and/or cholesterol during TORISEL (temsirolimus injection) treatment. This may require initiation of, or increase in the dose of, lipid-lowering agents [see WARNINGS AND PRECAUTIONS].
• Bowel Perforation
  Patients should be warned of the possibility of bowel perforation. Patients should be directed to report promptly any new or worsening abdominal pain or blood in their stools [see WARNINGS AND PRECAUTIONS].
• Renal Failure
  Patients should be informed of the risk of renal failure [see WARNINGS AND PRECAUTIONS].
• Wound Healing Complications
  Patients should be advised of the possibility of abnormal wound healing if they have surgery within a few weeks of initiating therapy or during therapy [see WARNINGS AND PRECAUTIONS].
• Intracerebral Bleeding
  Patients with CNS tumors and/or receiving anticoagulants should be informed of the increased risk of developing intracerebral bleeding (including fatal outcomes) while on TORISEL [see WARNINGS AND PRECAUTIONS].
• Medications that can interfere with TORISEL (temsirolimus injection)
  Some medicines can interfere with the breakdown or metabolism of TORISEL (temsirolimus injection) . In particular, patients should be directed to inform their physician if they are taking any of the following: Protease inhibitors, anti-epileptic medicines including carbamazepine, phenytoin, and barbiturates, St. John's Wort, rifampicin, rifabutin, nefazodone or selective serotonin re-uptake inhibitors used to treat depression, antibiotics or antifungal medicines used to treat infections [see WARNINGS AND PRECAUTIONS].
• Vaccinations
  Patients should be advised that vaccinations may be less effective while being treated with TORISEL (temsirolimus injection) . In addition, the use of live vaccines, and close contact with those who have received live vaccines, while on TORISEL should be avoided. [see WARNINGS AND PRECAUTIONS].
• Pregnancy
  TORISEL (temsirolimus injection) can cause fetal harm. Women of childbearing potential should be advised to avoid becoming pregnant throughout treatment and for 3 months after TORISEL (temsirolimus injection) therapy has stopped. Men with partners of childbearing potential should use reliable contraception throughout treatment and are recommended to continue this for 3 months after the last dose of TORISEL. [see WARNINGS AND PRECAUTIONS].

Last reviewed on RxList: 8/5/2010
This monograph has been modified to include the generic and brand name in many instances.