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In this Article

• What is temsirolimus (Torisel)?
• What are the possible side effects of temsirolimus (Torisel)?
• What is the most important information I should know about temsirolimus (Torisel)?
• What should I discuss with my doctor before receiving temsirolimus (Torisel)?
• How is temsirolimus given (Torisel)?
• What happens if I miss a dose (Torisel)?
• What happens if I overdose (Torisel)?
• What should I avoid while receiving temsirolimus (Torisel)?
• What other drugs will affect temsirolimus (Torisel)?
• Where can I get more information?

What happens if I miss a dose (Torisel)?

Call your doctor if you miss an appointment for your temsirolimus injection.

What happens if I overdose (Torisel)?

Seek emergency medical attention if you think you have received too much of this medicine.

Overdose symptoms may include black or bloody stools, severe stomach pain, confusion, unusual thoughts or behavior, sudden numbness or weakness, sudden headache, problems with vision or speech, pain or swelling in one or both legs, or seizure (convulsions).

What should I avoid while receiving temsirolimus (Torisel)?

Avoid contact with people who have colds, the flu, or other contagious illnesses. Contact your doctor immediately if you develop signs of infection.

Do not receive a "live" vaccine while you are being treated with temsirolimus, and avoid coming into contact with anyone who has recently received a live vaccine. There is a chance that the virus could be passed on to you.

Grapefruit and grapefruit juice may interact with temsirolimus and lead to potentially dangerous effects. Discuss the use of grapefruit products with your doctor. Do not increase or decrease the amount of grapefruit products in your diet without first talking to your doctor.

What other drugs will affect temsirolimus (Torisel)?

Before receiving temsirolimus, tell your doctor if you are using any of the following drugs:

• dexamethasone (Decadron, Hexadrol);
• rifabutin (Mycobutin);
• rifampin (Rifadin, Rimactane, Rifater);
• St. John's wort;
• sunitinib (Sutent);
• a blood thinner such as warfarin (Coumadin);
• insulin or diabetes medications you take by mouth;
• an antibiotic such as clarithromycin (Biaxin), telithromycin (Ketek), and others;
• an antifungal medication such as itraconazole (Sporanox), ketoconazole (Nizoral), or voriconazole (Vfend);
• HIV/AIDS medicine such as atazanavir (Reyataz), indinavir (Crixivan), nelfinavir (Viracept), ritonavir (Norvir), or saquinavir (Invirase, Fortovase); or
• seizure medication such as carbamazepine (Carbatrol, Tegretol), phenytoin (Dilantin), or phenobarbital (Luminal, Solfoton).

This list is not complete and there may be other drugs not listed that can affect temsirolimus. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

Where can I get more information?

Your pharmacist can provide more information about temsirolimus.

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