"By Kathleen Doheny
WebMD Health News
Reviewed by Arefa Cassoobhoy, MD, MPH
March 10, 2015 -- Drugs known as biologics have grabbed headlines over the years, both for their potential in fighting cancer and other diseases, and f"...
IMPORTANT: HOW TO USE THIS INFORMATION: This is a summary and does NOT have all possible information about this product. This information does not assure that this product is safe, effective, or appropriate for you. This information is not individual medical advice and does not substitute for the advice of your health care professional. Always ask your health care professional for complete information about this product and your specific health needs.
DEXRAZOXANE (EXTRAVASATION) - INJECTION
COMMON BRAND NAME(S): Totect
USES: Dexrazoxane is used to reduce serious tissue injury if doxorubicin or a similar cancer chemotherapy medication has leaked out of the vein into the surrounding tissue. Dexrazoxane can help prevent the need for surgery to repair the tissue damage.
OTHER USES: This section contains uses of this drug that are not listed in the approved professional labeling for the drug but that may be prescribed by your health care professional. Use this drug for a condition that is listed in this section only if it has been so prescribed by your health care professional.
Dexrazoxane is also available in another brand that is used to reduce the risk and severity of heart damage caused by doxorubicin treatment and similar cancer chemotherapy medications.
HOW TO USE: Read the Patient Information Leaflet if available from your pharmacist before you start using dexrazoxane. If you have any questions, ask your doctor or pharmacist.
This medication is given by a health care professional. It is injected slowly into a vein over 1 to 2 hours.
When used to reduce the risk of tissue injury from chemotherapy injection leakage, dexrazoxane is given as directed by your doctor, usually as soon as possible (within 6 hours of the injection leakage) once daily for 3 days.
If skin contact should occur, wash the area with plenty of soap and water. If irritation occurs, contact your doctor right away.
Tell your doctor if the condition around your injection site persists or worsens.
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