home > drugs a-z list > totect (dexrazoxane for injection, intravenous infusion only) drug center > totect (dexrazoxane for injection, intravenous infusion only) drug - medication guide and patient information

TOTECT®
(dex-ra-ZOX-ane)
(dexrazoxane) for Injection

Read the Patient Information that comes with Totect (dexrazoxane for injection, intravenous infusion only ) ® before you receive treatment. There may be new information. This information does not take the place of talking to your healthcare provider about your medical condition or treatment.

What is Totect (dexrazoxane for injection, intravenous infusion only ) ®?

Totect (dexrazoxane for injection, intravenous infusion only ) ® is a prescription medicine used to treat people when anthracycline chemotherapy leaks from your vein into the tissue around the intravenous (IV) site.

Totect (dexrazoxane for injection, intravenous infusion only ) ® has not been studied in children.

What should I tell my healthcare provider before receiving Totect (dexrazoxane for injection, intravenous infusion only ) ®?

Before receiving Totect (dexrazoxane for injection, intravenous infusion only ) ®:

• tell your healthcare provider about all your medical conditions including if you have any kidney problems.
• tell your healthcare provider about all the medicines you take, including prescription and nonprescription medicines, vitamins, herbal or dietary supplements. Know the medicines you take. Keep a list of them and show it to your healthcare provider and pharmacist when you get a new medicine.
• tell your healthcare provider if you use a topical dimethylsulfoxide (DMSO). Topical DMSO should not be used in combination with Totect (dexrazoxane for injection, intravenous infusion only ) ® since it may lessen the effect of Totect (dexrazoxane for injection, intravenous infusion only ) ®.
• tell your healthcare provider if you are pregnant, could be pregnant, or are planning to become pregnant, or are breast-feeding.

It is not known if Totect (dexrazoxane for injection, intravenous infusion only ) ® passes into your breast milk. You and your doctor should decide if you will receive Totect (dexrazoxane for injection, intravenous infusion only ) ® or breast feed. You should not do both. Talk to your doctor about the best way to feed your baby if you take Totect (dexrazoxane for injection, intravenous infusion only ) ®. Do not breast feed while taking Totect (dexrazoxane for injection, intravenous infusion only ) ®.

How will I receive Totect (dexrazoxane for injection, intravenous infusion only ) ®?

• Totect (dexrazoxane for injection, intravenous infusion only ) ® is given to you in your healthcare provider's office, clinic or hospital.
• Totect (dexrazoxane for injection, intravenous infusion only ) ® is infused into a vein for 1 to 2 hours each day for three days.

What are the possible side effects of Totect (dexrazoxane for injection, intravenous infusion only ) ®?

Totect (dexrazoxane for injection, intravenous infusion only ) ® can cause serious side effects including:

• a decrease in white blood cell counts (leukopenia and neutropenia)
• a decrease in the blood cells which help your blood to clot (thrombocytopenia)

Blood tests may be needed to monitor for these side effects.

Common side effects:

• nausea
• fever
• pain at the intravenous site
• vomiting

Tell your healthcare provider if you have any side effect that bothers you or does not go away.

These are not all the possible side effects of Totect (dexrazoxane for injection, intravenous infusion only ) ®. For more information, ask your healthcare provider or pharmacist.

Talk to your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088 (1-800-332-1088) or at fda.gov/medwatch.

General Information about Totect (dexrazoxane for injection, intravenous infusion only ) ®

Medicines are sometimes prescribed for purposes other than those listed in a patient information leaflet.

This Patient Information summarizes the most important information about Totect (dexrazoxane for injection, intravenous infusion only ) ®. If you would like more information, talk with your healthcare provider. You can ask your healthcare provider or pharmacist for information about Totect (dexrazoxane for injection, intravenous infusion only ) ® that is written for health professionals.

For more information, go to www.totect (dexrazoxane for injection, intravenous infusion only ) .com or call 1-866-914-2922.

What are the ingredients in Totect®?

Active ingredient: dexrazoxane

Inactive ingredients: hydrochloric acid, sodium lactate, water for injection, sodium hydroxide and lactic acid

Last reviewed on RxList: 9/30/2009
This monograph has been modified to include the generic and brand name in many instances.