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Brand Names: Totect, Zinecard

Generic Name: dexrazoxane (Pronunciation: dex ray ZOX ane)

• What is dexrazoxane (Totect)?
• What are the possible side effects of dexrazoxane (Totect)?
• What is the most important information I should know about dexrazoxane (Totect)?
• What should I discuss with my health care provider before receiving dexrazoxane (Totect)?
• How is dexrazoxane given (Totect)?
• What happens if I miss a dose (Totect)?
• What happens if I overdose (Totect)?
• What should I avoid after receiving dexrazoxane (Totect)?
• What other drugs will affect dexrazoxane (Totect)?
• Where can I get more information?

What is dexrazoxane (Totect)?

Dexrazoxane is used to protect the heart from harmful side effects caused by doxorubicin (Adriamycin).

Dexrazoxane is used in women who are receiving doxorubicin for metastatic breast cancer.

Dexrazoxane may also be used for purposes not listed in this medication guide.

What are the possible side effects of dexrazoxane (Totect)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Tell your doctor at once if you have any of these serious side effects:

• fever, chills, body aches, flu symptoms;
• easy bruising or bleeding, weakness; or
• white patches or sores inside your mouth or on your lips.

Less serious side effects may include:

• hair loss;
• nausea, vomiting, diarrhea, loss of appetite;
• tired feeling;
• pain where the medicine is injected;

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about dexrazoxane (Totect)?

You should not receive this medication if your chemotherapy does not include doxorubicin or a similar medication such as daunorubicin (Cerubidine), epirubicin (Ellence), idarubicin (Idamycin), or mitoxantrone (Novantrone).

Before you receive dexrazoxane, tell your doctor if you are allergic to any drugs, or if you have kidney disease. You may need dose adjustments or special tests during treatment.

Tell your doctor at once if you have serious side effects such as fever, chills, body aches, flu symptoms, easy bruising or bleeding, weakness, or white patches or sores inside your mouth or on your lips.