"The U.S. Food and Drug Administration today expanded the approved uses of Abraxane (paclitaxel protein-bound particles for injectable suspension, albumin-bound) to treat patients with late-stage (metastatic) pancreatic cancer.
Totect Patient Information Including Side Effects
Brand Names: Totect, Zinecard
Generic Name: dexrazoxane (Pronunciation: dex ray ZOX ane)
- What is dexrazoxane (Totect)?
- What are the possible side effects of dexrazoxane (Totect)?
- What is the most important information I should know about dexrazoxane (Totect)?
- What should I discuss with my health care provider before receiving dexrazoxane (Totect)?
- How is dexrazoxane given (Totect)?
- What happens if I miss a dose (Totect)?
- What happens if I overdose (Totect)?
- What should I avoid after receiving dexrazoxane (Totect)?
- What other drugs will affect dexrazoxane (Totect)?
- Where can I get more information?
What is dexrazoxane (Totect)?
Dexrazoxane is used to protect the heart and other tissues from harmful side effects caused by certain cancer medications.
The Zinecard brand of dexrazoxane is used in women who are receiving doxorubicin for metastatic breast cancer.
The Totect brand of dexrazoxane is used in men or women to treat a condition called extravasation (es-TRA-va-ZAY-shun). Extravasation happens when an injected medicine escapes from the blood vessels and circulates into tissues in the body. Serious tissue damage can occur when extravasation happens during injection of certain cancer medications.
Dexrazoxane may also be used for purposes not listed in this medication guide.
What are the possible side effects of dexrazoxane (Totect)?
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Tell your doctor at once if you have any of these serious side effects:
- fever, chills, body aches, flu symptoms, sores in your mouth and throat;
- easy bruising, unusual bleeding (nose, mouth, vagina, or rectum), purple or red pinpoint spots under your skin; or
- bruising, swelling, warmth, redness, oozing, or bleeding of any surgical incision.
Less serious side effects may include:
- swelling in your hands or feet;
- hair loss;
- nausea, vomiting, diarrhea, loss of appetite;
- sore throat, trouble swallowing;
- dizziness, tired feeling; or
- pain, swelling, or redness where the medicine was injected.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Read the Totect (dexrazoxane for injection, intravenous infusion only) Side Effects Center for a complete guide to possible side effects
What is the most important information I should know about dexrazoxane (Totect)?
You should not receive Totect if you are pregnant. It could harm the unborn baby. If possible before you receive Totect, tell your doctor if you are pregnant. It is not known whether Zinecard will harm an unborn baby.
You should not receive this medication if your chemotherapy does not include doxorubicin or a similar medication such as daunorubicin (Cerubidine), epirubicin (Ellence), idarubicin (Idamycin), or mitoxantrone (Novantrone).
Before you receive dexrazoxane, tell your doctor if you have liver or kidney disease, or if you are pregnant or breast-feeding.
Tell your doctor at once if you have serious side effects such as fever, chills, body aches, flu symptoms, easy bruising or bleeding, or sores your mouth or throat.
In an emergency situation it may not be possible before you are treated to tell your caregivers about your health conditions or if you are pregnant or breast feeding. Make sure any doctor caring for you afterward knows that you have received Totect.
Additional Totect Information
- Totect Drug Interactions Center: dexrazoxane iv
- Totect Side Effects Center
- Totect Overview including Precautions
- Totect FDA Approved Prescribing Information including Dosage
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
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