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home > drugs a-z list > trandate (labetalol) drug center > trandate (labetalol) drug - medication guide and patient information
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Trandate
What are beta blockers and how do they work?
Beta blockers, also known as beta-adrenergic blocking agents, are a class of drugs that works by blocking the neurotransmitters norepinephrine and epinephrine from binding to receptors. There are three known types of beta receptors, known as beta1 (β1), beta2 (β2) and beta3 (β3).
- β1-adrenergic receptors are located commonly in the heart and kidneys.
- β2-adrenergic receptors are located mainly in the lungs, gastrointestinal tract, liver, uterus, vascular smooth muscle, and skeletal muscle.
- β3- adrenergic receptors are located in fat cells.
When the neurotransmitters are prevented from binding to the receptors, it in turn causes the effects of adrenaline (epinephrine) to be blocked. This action allows the he...
Trandate
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PATIENT INFORMATION
As with all drugs with beta-blocking activity, certain advice to patients being treated with labetalol HCl is warranted. This information is intended to aid in the safe and effective use of this medication. It is not a disclosure of all possible adverse or intended effects. While no incident of the abrupt withdrawal phenomenon (exacerbation of angina pectoris) has been reported with labetalol HCl, dosing with Trandate (labetalol) Tablets should not be interrupted or discontinued without a physician's advice. Patients being treated with Trandate (labetalol) Tablets should consult a physician at any signs or symptoms of impending cardiac failure or hepatic dysfunction (see WARNINGS). Also, transient scalp tingling may occur, usually when treatment with Trandate Tablets is initiated (see ADVERSE REACTIONS).
Last reviewed on RxList: 1/3/2011
This monograph has been modified to include the generic and brand name in many instances.
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