Transderm Scop (Scopolamine) Drug Information: Description, User Reviews, Drug Side Effects, Interactions

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May 26, 2012

Transderm Scop

Travel Medicine »

Why should travelers see a physician before they leave on a trip?

Travelers should see a physician before leaving for a trip if

they are going to developing countries,
they are visiting sites that are not on the usual tourist routes or traveling to high altitudes,
they have chronic diseases that could be affected by travel,
they are visiting countries that require vaccinations before they allow travelers to enter the country.

The goal of a pre-travel medical evaluation is to help travelers protect themselves against (1) common diseases that may be mild but that will disrupt their trip, and (2) less common diseases that may be serious or even fatal. All travelers need to be up to date on routine vaccines they would normally get if they were not traveling. For example, an annual influenza vaccination (flu shot) is recommended if traveling during influenza season. Travelers should also be up to date on te...

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Transderm Scop

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TRANSDERM SCOP® (Novartis Consumer)
(transdermal scopolamine) 1.5 mg
Transdermal Therapeutic System
Programmed to deliver in-vivo approximately 1.0 mg of scopolamine over 3 days

DRUG DESCRIPTION

The Transderm Scop (transdermal scopolamine) system is a circular flat patch designed for continuous release of scopolamine following application to an area of intact skin on the head, behind the ear. Each system contains 1.5 mg of scopolamine base. Scopolamine is (alpha)-(hydroxymethyl) benzeneacetic acid 9-methyl-3-oxa-9-azatricyclo [3.3.1.0 ^2,4] non-7-yl ester. The empirical formula is C ₁₇H ₂₁NO _4. and its structural formula is:

Scopolamine is a viscous liquid that has a molecular weight of 303.35 and a pKa of 7.55-7.81. The Transderm Scop (scopolamine) system is a film 0.2 mm thick and 2.5 cm ², with four layers. Proceeding from the visible surface towards the surface attached to the skin, these layers are: (1) a backing layer of tan-colored, aluminized, polyester film; (2) a drug reservoir of scopolamine, light mineral oil, and polyisobutylene; (3) a microporous polypropylene membrane that controls the rate of delivery of scopolamine from the system to the skin surface; and (4) an adhesive formulation of mineral oil, polyisobutylene, and scopolamine. A protective peel strip of siliconized polyester, which covers the adhesive layer, is removed before the system is used. The inactive components, light mineral oil (12.4 mg) and polyisobutylene (11.4 mg), are not released from the system.

What are the possible side effects of scopolamine transdermal (Transderm-Scop)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Remove the scopolamine transdermal patch and call your doctor at once if you have any of these serious side effects:

eye pain or redness, seeing halos around lights;
blurred vision and increased sensitivity to light;
confusion, agitation, extreme fear, hallucinations, unusual thoughts or behavior; or
urinating less...

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What are the precautions when taking scopolamine (Transderm Scop)?

Before using scopolamine, tell your doctor or pharmacist if you are allergic to it; or to other belladonna alkaloids (e.g., atropine); or if you have any other allergies. This product may contain inactive ingredients (such as adhesives), which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have: a certain type of glaucoma (narrow-angle).

Before using this medication, tell your doctor or pharmacist your medical history, especially of: a certain type of glaucoma (wide-angle), seizures, mental/mood disorders (e.g., psychosis, anxiety), uncontrolled pain, breathing problems (e.g., asthma,...

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Last reviewed on RxList: 8/1/2007
This monograph has been modified to include the generic and brand name in many instances.