Tranxene (Clorazepate Dipotassium) Drug Information: Description, User Reviews, Drug Side Effects, Interactions

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May 26, 2012

Tranxene

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Anxiety is both a normal and useful response to potentially stressful or dangerous situations. It helps by increasing our awareness of what's going on around us and in other ways. For most people, the anxiety is short lived and normally goes away once the situation has passed. But that is not the case for an estimated 40 million adults in the United States who have some type of anxiety disorder and experience ongoing and unwarranted psychological distress. That distress may also manifest itself in physical symptoms such as muscle tension, headaches, or chest pain.

Anxiety medications include multiple types of drugs that are used to treat the symptoms of anxiety disorders. The three most commonly prescribed types of anxiety medication are antidepressants, anti-anxiety medications -- also known as anxiolytics -- and beta-blockers. The first two types of anxiety medications work primarily by affecting the ba...

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Tranxene

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Tranxene T-TAB® Tablets
(clorazepate dipotassium) Tablets, USP

DRUG DESCRIPTION

Chemically, TRANXENE (clorazepate dipotassium) is a benzodiazepine. The empirical formula is C₁₆H₁₁ClK₂N₂O₄; the molecular weight is 408.92; 1H-1, 4-Benzodiazepine-3-carboxylic acid, 7-chloro-2,3-dihydro-2-oxo-5-phenyl-, potassium salt compound with potassium hydroxide (1:1) and the structural formula may be represented as follows:

Tranxene T-TAB® (clorazepate dipotassium) Structural Formula Illustration

The compound occurs as a fine, light yellow, practically odorless powder. It is insoluble in the common organic solvents, but very soluble in water. Aqueous solutions are unstable, clear, light yellow, and alkaline.

TRANXENE (clorazepate dipotassium) T-TAB tablets contain either 3.75 mg, 7.5 mg or 15 mg of clorazepate dipotassium for oral administration.

Inactive ingredients for TRANXENE (clorazepate dipotassium) T-TAB Tablets: Colloidal silicon dioxide, FD&C Blue No. 2 (3.75 mg only), FD&C Yellow No. 6 (7.5 mg only), FD&C Red No. 3 (15 mg only), magnesium oxide, magnesium stearate, microcrystalline cellulose, potassium carbonate, potassium chloride, and talc.

What are the possible side effects of clorazepate (Tranxene SD, Tranxene T-Tab)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have any of these serious side effects:

confusion, unusual thoughts or behavior;
depressed mood, thoughts of suicide or hurting yourself;
muscle twitching, tremor; or
problems with urination.

Less serious side effects may include:

drowsiness,...

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What are the precautions when taking clorazepate dipotassium (Tranxene)?

Before taking this medication, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: liver disease, kidney disease, lung/breathing problems (e.g., COPD, sleep apnea), drug or alcohol abuse.

This drug may make you dizzy or drowsy or cause blurred vision. Do not drive, use machinery, or do any activity that requires alertness or clear vision until you are sure you can perform such activities safely. Avoid alcoholic beverages.

Caution is advised when using this drug in the elderly because they...

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Last reviewed on RxList: 7/2/2010
This monograph has been modified to include the generic and brand name in many instances.