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(amino acid) Injection
10% Travasol® (Amino Acid) Injection is a sterile, nonpyrogenic hypertonic solution of essential and nonessential amino acids in a Pharmacy Bulk Package. A Pharmacy Bulk Package is a container of a sterile preparation for parenteral use that contains many single doses. The contents are intended for use in a pharmacy admixture program and are restricted to the preparation of admixtures for intravenous infusion.
The Viaflex® plastic container is fabricated from a specially formulated polyvinyl chloride (PL 146® Plastic). Exposure to temperatures above 25ºC/77ºF during transport and storage will lead to minor losses in moisture content. Higher temperatures lead to greater losses. It is unlikely that these minor losses will lead to clinically significant changes within the expiration period. The amount of water that can permeate from inside the container into the overwrap is insufficient to affect the solution significantly. Solutions in contact with the plastic container can leach out certain of its chemical components in very small amounts within the expiration period, e.g., di-2-ethylhexyl phthalate (DEHP), up to 5 parts per million; however, the safety of the plastic has been confirmed in tests in animals according to USP biological test for plastic containers as well as by tissue culture toxicity studies.
|Amino acids||10 g|
|Total nitrogen||1.65 g|
|pH||6.0 (5.0 to 7.0)|
|(pH adjusted with glacial acetic acid and may have been adjusted with sodium hydroxide.)|
|Essential Amino Acids|
|Leucine - C6H13NO2||730 mg|
|Isoleucine - C6H13NO2||600 mg|
|Lysine (added as the hydrochloride salt) - C6H14N2O2||580 mg|
|Valine - C5H11NO2||580 mg|
|Phenylalanine - C9H11NO2||560 mg|
|Histidine - C6H9N3O2||480 mg|
|Threonine - C4H9NO3||420 mg|
|Methionine - C5H11NO2S||400 mg|
|Tryptophan - C11H12N2O2||180 mg|
|Nonessential Amino Acids|
|Alanine - C3H7NO2||2.07 g|
|Arginine - C6H14N4O2||1.15 g|
|Glycine - C2H5NO2||1.03 g|
|Proline - C5H9NO2||680 mg|
|Serine - C3H7NO3||500 mg|
|Tyrosine - C9H11NO3||40 mg|
|Anion profiles per liter*|
|Osmolarity (Calc.)||998 mOsmol/L|
| *Balanced by ions from amino acids.
†derived from pH adjustment with glacial acetic acid
‡contributed by the lysine hydrochloride
Last reviewed on RxList: 5/5/2009
This monograph has been modified to include the generic and brand name in many instances.
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