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Travasol

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Travasol

TRAVASOL
(amino acid) Injection

DRUG DESCRIPTION

10% Travasol® (Amino Acid) Injection is a sterile, nonpyrogenic hypertonic solution of essential and nonessential amino acids in a Pharmacy Bulk Package. A Pharmacy Bulk Package is a container of a sterile preparation for parenteral use that contains many single doses. The contents are intended for use in a pharmacy admixture program and are restricted to the preparation of admixtures for intravenous infusion.

The Viaflex® plastic container is fabricated from a specially formulated polyvinyl chloride (PL 146® Plastic). Exposure to temperatures above 25C/77F during transport and storage will lead to minor losses in moisture content. Higher temperatures lead to greater losses. It is unlikely that these minor losses will lead to clinically significant changes within the expiration period. The amount of water that can permeate from inside the container into the overwrap is insufficient to affect the solution significantly. Solutions in contact with the plastic container can leach out certain of its chemical components in very small amounts within the expiration period, e.g., di-2-ethylhexyl phthalate (DEHP), up to 5 parts per million; however, the safety of the plastic has been confirmed in tests in animals according to USP biological test for plastic containers as well as by tissue culture toxicity studies.

Amino acids 10 g
Total nitrogen 1.65 g
pH 6.0 (5.0 to 7.0)
(pH adjusted with glacial acetic acid and may have been adjusted with sodium hydroxide.)
Essential Amino Acids
Leucine - C6H13NO2 730 mg
Isoleucine - C6H13NO2 600 mg
Lysine (added as the hydrochloride salt) - C6H14N2O2 580 mg
Valine - C5H11NO2 580 mg
Phenylalanine - C9H11NO2 560 mg
Histidine - C6H9N3O2 480 mg
Threonine - C4H9NO3 420 mg
Methionine - C5H11NO2S 400 mg
Tryptophan - C11H12N2O2 180 mg
Nonessential Amino Acids
Alanine - C3H7NO2 2.07 g
Arginine - C6H14N4O2 1.15 g
Glycine - C2H5NO2 1.03 g
Proline - C5H9NO2 680 mg
Serine - C3H7NO3 500 mg
Tyrosine - C9H11NO3 40 mg
Anion profiles per liter*
Acetate 88 mEq
Chloride 40 mEq
Osmolarity (Calc.) 998 mOsmol/L
*Balanced by ions from amino acids.
derived from pH adjustment with glacial acetic acid
contributed by the lysine hydrochloride

Last reviewed on RxList: 5/5/2009
This monograph has been modified to include the generic and brand name in many instances.

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