"The US Food and Drug Administration (FDA) has approved Akorn Inc's phenylephrine hydrochloride ophthalmic solution (2.5% and 10%), the company has announced.
The alpha-1 adrenergic receptor agonist is commonly used by optometrists, ophtha"...
(travoprost) Ophthalmic Solution 0.004%
Travoprost is a synthetic prostaglandin F analogue. Its chemical name is [1R-[lα(Z),2β(lE,3R*),3α,5α]]-7-[3,5-Dihydroxy-2-[3-hydroxy-4-[3-(trifluoromethyl)phenoxy]-1 -butenyl]cyclopentyl]-5-heptenoic acid, 1 -methylethylester. It has a molecular formula of C26H35F3O6 and a molecular weight of 500.55. The chemical structure of travoprost is:
Travoprost is a clear, colorless to slightly yellow oil that is very soluble in acetonitrile, methanol, octanol, and chloroform. It is practically insoluble in water.
TRAVATAN Z® (travoprost ophthalmic solution) 0.004% is supplied as sterile, buffered aqueous solution of travoprost with a pH of approximately 5.7 and an osmolality of approximately 290 mOsmol/kg.
TRAVATAN Z® contains Active: travoprost 0.04 mg/mL; Inactives: polyoxyl 40 hydrogenated castor oil, sofZia® (boric acid, propylene glycol, sorbitol, zinc chloride), sodium hydroxide and/or hydrochloric acid (to adjust pH) and purified water, USP. Preserved in the bottle with an ionic buffered system, sofZia®.
What are the possible side effects of travoprost ophthalmic (Travatan, Travatan Z)?
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Stop using travoprost ophthalmic and call your doctor at once if you have any of these serious side effects:
- redness, swelling, itching, or pain in or around your eye;
- oozing or discharge from your eye;
- increased sensitivity to light;
- vision changes; or
- chest pain.
Less serious side effects may include:
- mild eye...
What are the precautions when taking travoprost ophthalmic solution (Travatan Z)?
Before using travoprost, tell your doctor or pharmacist if you are allergic to it; or to similar drugs (e.g., bimatoprost, latanoprost); or if you have any other allergies. This product may contain inactive ingredients (such as preservatives like benzalkonium chloride found in some brands), which can cause allergic reactions or other problems. Talk to your pharmacist for more details.
Before using this medication, tell your doctor or pharmacist your medical history, especially of: eye problems (e.g., macular edema, iritis, uveitis, lens extraction/aphakia).
If you develop an eye infection or injury, or have eye surgery, check with your doctor about the continued use of your current bottle of travoprost. You may be advised to start using a new bottle.
This drug may...
Last reviewed on RxList: 9/19/2011
This monograph has been modified to include the generic and brand name in many instances.
Additional Travatan Z Information
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