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home > drugs a-z list > treanda (bendamustine hydrochloride injection) drug center > treanda (bendamustine hydrochloride injection) drug - overdosage and contraindications
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Leukemia facts
- Leukemia is a cancer of the blood cells.
- While the exact cause(s) of leukemia is not known, risk factors have been identified.
- Leukemias are grouped by how quickly the disease develops (acute or chronic) as well as by the type of blood cell that is affected (lymphocytes or myelocytes). The four main types of leukemia include acute lymphocytic leukemia (ALL), chronic lymphocytic leukemia (CLL), acute myelocytic leukemia (AML), and chronic myelocytic leukemia (CML).
- People with leukemia are at significantly increased risk for developing infections, anemia, and bleeding. Other symptoms and signs include easy bruising, weight loss, night sweats, and unexplained fevers.
- The diagnosis of leukemia is supported by findings of the
medical history and examination, and examining blood
and bone marrow samples under a microscope.
- Tre...
Treanda
OVERDOSE
The intravenous LD50 of bendamustine HCl is 240 mg/m² in the mouse and rat. Toxicities included sedation, tremor, ataxia, convulsions and respiratory distress.
Across all clinical experience, the reported maximum single dose received was 280 mg/m². Three of four patients treated at this dose showed ECG changes considered dose-limiting at 7 and 21 days post-dosing. These changes included QT prolongation (one patient), sinus tachycardia (one patient), ST and T wave deviations (two patients) and left anterior fascicular block (one patient). Cardiac enzymes and ejection fractions remained normal in all patients.
No specific antidote for TREANDA (bendamustine hydrochloride injection) overdose is known. Management of overdosage should include general supportive measures, including monitoring of hematologic parameters and ECGs.
CONTRAINDICATIONS
TREANDA (bendamustine hydrochloride injection) is contraindicated in patients with a known hypersensitivity (e.g., anaphylactic and anaphylactoid reactions) to bendamustine or mannitol. [See WARNINGS AND PRECAUTIONS]
Last reviewed on RxList: 2/16/2011
This monograph has been modified to include the generic and brand name in many instances.
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