December 6, 2016
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Trecator

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Trecator

Trecator®
(ethionamide) Tablets USP




To reduce the development of drug-resistant bacteria and maintain the effectiveness of Trecator and other antibacterial drugs, Trecator should be used only to treat infections that are proven or strongly suspected to be caused by bacteria.

DRUG DESCRIPTION

Trecator® (ethionamide tablets, USP) is used in the treatment of tuberculosis. The chemical name for ethionamide is 2-ethylthioisonicotinamide with the following structural formula:

Trecator®(ethionamide) Structural Formula Illustration

Ethionamide is a yellow crystalline, nonhygroscopic compound with a faint to moderate sulfide odor and a melting point of 162°C. It is practically insoluble in water and ether, but soluble in methanol and ethanol. It has a partition coefficient (octanol/water) Log P value of 0.3699. Trecator tablets contain 250 mg of ethionamide. The inactive ingredients present are croscarmellose sodium, FD&C Yellow #6, magnesium stearate, microcrystalline cellulose, polyethylene glycol, polyvinyl alcohol, povidone, silicon dioxide, talc, and titanium dioxide.

What are the possible side effects of ethionamide (Trecator)?

If you experience any of the following serious side effects, stop taking ethionamide and seek emergency medical attention:

  • an allergic reaction (difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives);
  • yellow skin or eyes;
  • dark urine;
  • numbness or tingling in your hands or feet;
  • seizures;
  • blurred or double vision; or
  • confusion or abnormal behavior.

Other, less serious side effects may be more likely to occur. Continue to take ethionamide and talk to your doctor if you...

Read All Potential Side Effects and See Pictures of Trecator »

What are the precautions when taking ethionamide tablets (Trecator)?

Before taking ethionamide, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: liver disease, kidney disease, underactive thyroid (hypothyroidism), eye problems (such as optic neuritis, cataracts, diabetic retinopathy).

Alcohol may increase the risk of liver disease or mental/mood changes. Avoid alcoholic beverages while using this medication.

Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal...

Read All Potential Precautions of Trecator »

Last reviewed on RxList: 9/8/2016
This monograph has been modified to include the generic and brand name in many instances.

Report Problems to the Food and Drug Administration

 

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.


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