Trelstar Depot (Triptorelin pamoate) Drug Information: Description, User Reviews, Drug Side Effects, Interactions

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February 9, 2012

Trelstar Depot

Prostate Cancer »

What is the prostate gland?

The prostate gland is an organ that is located at the base or outlet (neck) of the urinary bladder. (See the diagram that follows.) The gland surrounds the first part of the urethra. The urethra is the passage through which urine drains from the bladder to exit from the penis. One function of the prostate gland is to help control urination by pressing directly against the part of the urethra that it surrounds. The main function of the prostate gland is to produce some of the substances that are found in normal semen, such as minerals and sugar. Semen is the fluid that transports the sperm to assist with reproduction. A man can manage quite well, however, without his prostate gland. (See the section on surgical treatment for prostate cancer.)

In a young man, the normal prostate gland is the size of a walnut (<30g). During normal aging, however, the gland usually grows larger. This hormone-related enlargement with aging is called b...

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TRELSTAR®
(triptorelin pamoate) for Injectable Suspension

DRUG DESCRIPTION

TRELSTAR is a white to slightly yellow lyophilized cake. When reconstituted, TRELSTAR has a milky appearance. It contains a pamoate salt of triptorelin, a synthetic decapeptide agonist analog of gonadotropin releasing hormone (GnRH). The chemical name of triptorelin pamoate is 5-oxo-L-prolyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosyl-D-tryptophyl-L-leucyl- L-arginyl-L-prolylglycine amide (pamoate salt). The empirical formula is C₆₄H₈₂N₁₈O₁₃ · C₂₃H₁₆O₆ and the molecular weight is 1699.9. The structural formula is:

TRELSTAR® (triptorelin) Structural Formula Illustration

The TRELSTAR products are sterile, lyophilized biodegradable microgranule formulations supplied as single dose vials. Refer to Table 5 for the composition of each TRELSTAR product.

Table 5: TRELSTAR Composition

Ingredients	TRELSTAR 3.75 mg	TRELSTAR 11.25 mg	TRELSTAR 22.5 mg
triptorelin pamoate (base units)	3.75 mg	11.25 mg	22.5 mg
poly-d,l-lactide-coglycolide	136 mg	118 mg	182 mg
mannitol, USP	69 mg	76 mg	68 mg
carboxymethylcellulose sodium, USP	24 mg	27 mg	24 mg
polysorbate 80, NF	1.6 mg	1.8 mg	1.6 mg

When 2 mL sterile water is added to the vial containing TRELSTAR and mixed, a suspension is formed which is intended as an intramuscular injection. TRELSTAR is available in two packaging configurations: (a) TRELSTAR vial alone or (b) TRELSTAR vial plus a MIXJECT vial adapter, and a separate pre-filled syringe that contains sterile water for injection, USP, 2 mL, pH 6 to 8.5.

What are the possible side effects of triptorelin (Trelstar Depot)?

If you experience any of the following serious side effects, stop using triptorelin and seek emergency medical attention or contact your doctor immediately:

an allergic reaction (difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives);
difficulty urinating or blood in the urine;
bone pain; or
numbness, tingling, weakness, or paralysis.

Other, less serious side effects may be more likely to occur. Talk to your doctor if you...

Read All Potential Side Effects and See Pictures of Trelstar Depot »

What are the precautions when taking triptorelin pamoate (Trelstar Depot)?

Before using triptorelin, tell your doctor or pharmacist if you are allergic to it; or to other LHRH-type drugs (such as leuprolide); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: kidney disease, liver disease, personal or family history of weak/broken bones (osteoporosis), diabetes, heart disease (such as heart attack), stroke, family history of sudden cardiac death.

This drug may make you dizzy. Do not drive, use machinery, or do any activity that requires alertness until you are sure you can perform such activities safely. Limit alcoholic...

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Last reviewed on RxList: 6/28/2011
This monograph has been modified to include the generic and brand name in many instances.