Trelstar (Triptorelin Pamoate for Injectable Suspension) Drug Information: Description, User Reviews, Drug Side Effects, Interactions

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May 27, 2012

Trelstar

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The prostate gland is an organ that is located at the base or outlet (neck) of the urinary bladder. (See the diagram that follows.) The gland surrounds the first part of the urethra. The urethra is the passage through which urine drains from the bladder to exit from the penis. One function of the prostate gland is to help control urination by pressing directly against the part of the urethra that it surrounds. The main function of the prostate gland is to produce some of the substances that are found in normal semen, such as minerals and sugar. Semen is the fluid that transports the sperm to assist with reproduction. A man can manage quite well, however, without his prostate gland. (See the section on surgical treatment for prostate cancer.)

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TRELSTAR®
(triptorelin pamoate) for Injectable Suspension Intramuscular Use.

DRUG DESCRIPTION

TRELSTAR (triptorelin pamoate for injectable suspension) is a white to slightly yellow lyophilized cake. When reconstituted, TRELSTAR (triptorelin pamoate for injectable suspension) has a milky appearance. It contains a pamoate salt of triptorelin, a synthetic decapeptide agonist analog of gonadotropin releasing hormone (GnRH). The chemical name of triptorelin pamoate is 5-oxo-L-prolyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosyl-D-tryptophyl-L-leucyl-L-arginyl-L-prolylglycine amide (pamoate salt). The empirical formula is C₆₄H₈₂N₁₈O₁₃ · C₂₃H₁₆O₆ and the molecular weight is 1699.9. The structural formula is:

TRELSTAR (triptorelin pamoate) Structural Formula Illustration

The TRELSTAR (triptorelin pamoate for injectable suspension) products are sterile, lyophilized biodegradable microgranule formulations supplied as single dose vials. Refer to Table 5 for the composition of each TRELSTAR (triptorelin pamoate for injectable suspension) product.

Table 5. TRELSTAR (triptorelin pamoate for injectable suspension) Composition

Ingredients	TRELSTAR 3.75 mg	TRELSTAR 11.25 mg	TRELSTAR 22.5 mg
triptorelin pamoate (base units)	3.75 mg	11.25 mg	22.5 mg
poly-d,l-lactide-co-glycolide	136 mg	118 mg	182 mg
mannitol, USP	69 mg	76 mg	68 mg
carboxymethylcellulose sodium, USP	24 mg	27 mg	24 mg
polysorbate 80, NF	1.6 mg	1.8 mg	1.6 mg

When 2 mL sterile water is added to the vial containing TRELSTAR (triptorelin pamoate for injectable suspension) and mixed, a suspension is formed which is intended as an intramuscular injection. TRELSTAR (triptorelin pamoate for injectable suspension) is available in two packaging configurations: (a) TRELSTAR (triptorelin pamoate for injectable suspension) vial alone or (b) TRELSTAR (triptorelin pamoate for injectable suspension) vial plus a MIXJECT vial adapter, and a separate pre-filled syringe that contains sterile water for injection, USP, 2 mL, pH 6 to 8.5.

What are the precautions when taking triptorelin pamoate for injectable suspension (Trelstar)?

Before taking this product, tell your doctor or pharmacist if you are allergic to either olmesartan, amlodipine, or hydrochlorothiazide; or to other angiotensin receptor blockers (such as losartan); or to ACE inhibitors (such as lisinopril); or to other calcium channel blockers (such as nifedipine); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: kidney disease (such as renal artery stenosis, anuria), loss of too much body water (dehydration), liver disease, gout, lupus, untreated mineral imbalance (such as high/low potassium, low magnesium, high...

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Last reviewed on RxList: 6/30/2011
This monograph has been modified to include the generic and brand name in many instances.