Trental (Pentoxifylline) Drug Information: Description, User Reviews, Drug Side Effects, Interactions

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May 26, 2012

Trental

Sickle Cell Disease (Sickle Cell Anemia) »

What is sickle cell anemia?

Sickle cell anemia (sickle cell disease) is a disorder of the blood caused by an inherited abnormal hemoglobin (an oxygen-carrying protein within the red blood cells). The abnormal hemoglobin causes distorted (sickled) red blood cells. The sickled red blood cells are fragile and prone to rupture. When the number of red blood cells decreases from rupture (hemolysis), anemia is the result. This condition is referred to as sickle cell anemia. The irregular sickled cells can also block blood vessels causing tissue and organ damage and pain.

Sickle cell anemia is one of the most common inherited blood anemias. The disease primarily affects Africans and African Americans. It is estimated that in the United States, some 50,000 African Americans are afflicted with the most severe form of sickle cell anemia. Overall, current estimates are that one in 1,875 U.S. African American is affected with sickle cell anemia./...

Read the Sickle Cell Disease (Sickle Cell Anemia) article »

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Trental User Reviews >>

Trental

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TRENTAL®
(pentoxifylline) Tablets, 400 mg

DRUG DESCRIPTION

TRENTAL® (pentoxifylline) tablets for oral administration contain 400 mg of the active drug and the following inactive ingredients: FD&C Red No. 3, hypromellose USP, magnesium stearate NF, polyethylene glycol NF, povidone USP, talc USP, titanium dioxide USP, and hydroxyethyl cellulose USP in an extended-release formulation. TRENTAL (pentoxifylline) is a tri-substituted xanthine derivative designated chemically as 1-(5-oxohexyl)-3, 7-dimethylxanthine that, unlike theophylline, is a hemorrheologic agent, i.e. an agent that affects blood viscosity. Pentoxifylline is soluble in water and ethanol, and sparingly soluble in toluene. The CAS Registry Number is 6493-05-6.

The chemical structure is:

TRENTAL®
(pentoxifylline) Structural Formula Illustration

What are the possible side effects of pentoxifylline (Pentoxil, Trental)?

If you experience any of the following serious side effects, stop taking pentoxifylline and seek medical attention:

an allergic reaction (difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives);
chest pain or an irregular heartbeat;
severe dizziness, headache, nosebleeds, or blurred vision;
nausea or vomiting; or
swollen feet or ankles.

Other, less serious side effects may be more likely to occur. Continue to take...

Read All Potential Side Effects and See Pictures of Trental »

What are the precautions when taking pentoxifylline (Trental)?

Before taking pentoxifylline, tell your doctor or pharmacist if you are allergic to it; or to caffeine, or theophylline; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: recent stroke, recent bleeding in the eye, kidney problems, recent major surgery, stomach ulcer.

This drug may rarely make you dizzy. Do not drive, use machinery, or do any activity that requires alertness until you are sure you can perform such activities safely. Limit alcoholic beverages.

Before having surgery, tell your doctor or dentist about all the products you use...

Read All Potential Precautions of Trental »

Last reviewed on RxList: 3/16/2009
This monograph has been modified to include the generic and brand name in many instances.