Clinical Use

Trental® (pentoxifylline) is indicated for the symptomatic treatment of:

• patients with chronic occlusive peripheral vascular disorders of the extremities;

In such patients Trental may give relief of signs and symptoms of impaired blood flow, such as intermittent claudication or trophic ulcers.

Recommended Dose and Dosage Adjustment

The recommended starting dosage of Trental (pentoxifylline) is 400 mg twice daily after meals. The usual dose is 400 mg twice or three times daily. A maximum of 400 mg three times daily should not be exceeded.

It may take up to two months to obtain full results.

Trental 400 mg sustained release tablets must be swallowed whole.

Storage And Stability

Store at room temperature (15 to 30 °C). Protect from light.

Protect from moisture and excessive heat.

Dosage Forms, Composition And Packaging

Composition

Trental sustained release tablets 400 mg contain 400 mg medicinal ingredient, pentoxifylline.

The qualitative formulation of Trental tablets is: pentoxifylline, benzyl alcohol, FD&C red no.3, hydroxyethyl cellulose, hydroxypropyl methylcellulose, magnesium stearate, polyethylene glycol 8000, povidone, talc, titanium dioxide.

Availability

Trental (pentoxifylline) is available as 400 mg, pink, oblong, film-coated, sustained release tablets, packed in Unit Pack boxes of 60 [4x15 clear PVC film and aluminium foil blisterpacked] tablets. One face is debossed with “Trental”, the other face is plain.

This leaflet was prepared by sanofi-aventis Canada Inc. Last revised: March 30, 2011

Last reviewed on RxList: 7/16/2012
This monograph has been modified to include the generic and brand name in many instances.