Overdosage with Trental (pentoxifylline) has been reported in children and adults. Symptoms appear to be dose related and usually occurred 4-5 hours after ingestion and lasted about 12 hours. Initial manifestations of acute overdose with pentoxifylline may be nausea, dizziness, tachycardia, fever, gastrointestinal bleeding – coffee-ground vomiting and areflexia. The highest amount ingested was 80 mg/kg with which flushing, hypotension, convulsions, somnolence, loss of consciousness, fever, and agitation have been observed. All patients recovered.
No specific antidote is known. In addition to symptomatic treatment and gastric lavage, special attention must be given to supporting respiration, maintaining systemic blood pressure, and controlling convulsions with intravenous diazepam. Activated charcoal has been used to absorb pentoxifylline in patients who have overdosed.
For management of a suspected drug overdose, contact your regional Poison Control Centre.
The use of Trental (pentoxifylline) is contraindicated in:
- Patients who are hypersensitive to pentoxifylline or other xanthines such as caffeine, theophylline and theobromine or to any ingredient in the formulation or component of the container (see Dosage Forms, Composition and Packaging).
- Patients with acute myocardial infraction;
- Patients with severe coronary artery disease when, in the physician's judgement, myocardial stimulation might prove harmful;
- Patients with hemorrhage (e.g. extensive retinal bleeding) or at risk of increased bleeding;
- Patients with peptic ulcers or recent history thereof.
Last reviewed on RxList: 7/16/2012
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