Trental Patient Information including How Should I Take

What should I discuss with my healthcare provider before taking pentoxifylline (Trental)?

You cannot take pentoxifylline if you have recently hemorrhaged (bled) in the eye or brain, or if you have an allergy to caffeine, theophylline (Theo-Dur, Theo-Bid), or theobromine.

Before taking this medication, tell your doctor if you

  • have an ulcer disease (stomach or duodenal ulcer);
  • have recently had any type of surgery (including dental);
  • have recently had a bleeding disorder; or
  • have any type of liver disease.

You may not be able to take pentoxifylline, or you may require a lower dose or special monitoring during treatment if you have any of the conditions listed above.

Pentoxifylline is in the FDA pregnancy category C. This means that it is not known whether pentoxifylline will harm an unborn baby. Do not take this medication without first talking to your doctor if you are pregnant.

Pentoxifylline passes into breast milk and may affect a nursing infant. Do not take this medication without first talking to your doctor if you are breast-feeding a baby.

How should I take pentoxifylline (Trental)?

Take pentoxifylline exactly as directed by your doctor. If you do not understand these instructions, ask your pharmacist, nurse, or doctor to explain them to you.

Take each dose with a full glass (8 ounces) of water.

Take pentoxifylline with food or an antacid to lessen stomach upset.

Pentoxifylline is usually taken three times a day. Follow your doctor's instructions. If you experience side effects, talk to your doctor. You may only need to take pentoxifylline twice a day.

Do not break, crush, or chew the tablets. Swallow them whole. They are specially coated to protect your stomach.

Do not stop taking this medication suddenly. It may take up to 8 weeks for you to see the beneficial effects of pentoxifylline, although you may begin to feel better as soon as 2 weeks after starting therapy.

Store pentoxifylline at room temperature away from moisture and heat.

Side Effects Centers

Trental - User Reviews

Trental User Reviews

Now you can gain knowledge and insight about a drug treatment with Patient Discussions.

Here is a collection of user reviews for the medication Trental sorted by most helpful. Patient Discussions FAQs

Report Problems to the Food and Drug Administration


You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

Women's Health

Find out what women really need.