"For the first time, an antidote to certain types of chemotherapy has been approved by the US Food and Drug Administration (FDA).
The product is uridine triacetate (Vistogard, Wellstat Therapeutics Corporation), and it is appr"...
Patients should be informed of the early signs and symptoms of toxicity, of the need to see their physician promptly if they occur, and the need for close follow-up, including periodic laboratory tests to monitor toxicity.
Both the physician and pharmacist should emphasize to the patient that the recommended dose is taken weekly in rheumatoid arthritis and psoriasis, and that mistaken daily use of the recommended dose has led to fatal toxicity.
Prescriptions should not be written or refilled on a PRN basis.
Patients should be informed of the potential benefit and risk in the use of methotrexate. The risk of effects on reproduction should be discussed with both male and female patients taking methotrexate.
Last reviewed on RxList: 5/5/2016
This monograph has been modified to include the generic and brand name in many instances.
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