"The U.S. Food and Drug Administration today expanded the approved use of Stivarga (regorafenib) to treat patients with advanced gastrointestinal stromal tumors (GIST) that cannot be surgically removed and no longer respond to other FDA-approved t"...
- Clinician Information:
Trexall Patient Information including If I Miss a Dose
In this Article
- What is methotrexate (Trexall)?
- What are the possible side effects of methotrexate (Trexall)?
- What is the most important information I should know about methotrexate (Trexall)?
- What should I discuss with my healthcare provider before taking methotrexate (Trexall)?
- How should I take methotrexate (Trexall)?
- What happens if I miss a dose (Trexall)?
- What happens if I overdose (Trexall)?
- What should I avoid while taking methotrexate (Trexall)?
- What other drugs will affect methotrexate (Trexall)?
- Where can I get more information?
What happens if I miss a dose (Trexall)?
Call your doctor if you miss a dose of methotrexate.
What happens if I overdose (Trexall)?
Seek emergency medical attention if you think you have used too much of this medicine. An overdose of methotrexate can be fatal.
Overdose symptoms may include pale skin, easy bruising or bleeding, unusual weakness, mouth sores, nausea, vomiting, black or bloody stools, coughing up blood or vomit that looks like coffee grounds, and urinating less than usual or not at all.
What should I avoid while taking methotrexate (Trexall)?
Avoid exposure to sunlight or artificial UV rays (sunlamps or tanning beds), especially if you are being treated for psoriasis. Methotrexate can make your skin more sensitive to sunlight and your psoriasis may worsen.
Avoid drinking alcohol while taking methotrexate.
What other drugs will affect methotrexate (Trexall)?
Before taking methotrexate, tell your doctor if you are using any of the following drugs:
- azathioprine (Imuran);
- chloramphenicol (Chloromycetin);
- hydroxychloroquine (Plaquenil, Quineprox);
- retinol, tretinoin (Retin-A), isotretinoin (Accutane);
- steroids (prednisone and others);
- sulfa drugs such as Azulfidine, Bactrim, or Septra;
- phenytoin (Dilantin);
- probenecid (Benemid);
- tetracycline (Brodspec, Panmycin, Sumycin, Tetracap);
- theophylline (Elixophyllin, Slo-Bid, Theobid, Theo-Dur);
- gold treatments such as auranofin (Ridura);
- oral diabetes medications such as acetohexamide (Dymelor), chlorpropamide (Diabinese), glipizide (Glucotrol), glimepiride (Amaryl), or tolbutamide (Orinase);
- a penicillin antibiotic such as ampicillin (Principen), amoxicillin (Amoxil, Trimox), dicloxacillin (Dynapen), nafcillin (Unipen), oxacillin (Bactocill), penicillamine (Cuprimine, Depen), or Bee-Pen, Pen-Vee K, Veetids;
- salicylates such as aspirin, Disalcid, Doan's Pills, Dolobid, Salflex, Tricosal, and others; or
- NSAIDs (non-steroidal anti-inflammatory drugs) such as ibuprofen (Motrin, Advil), diclofenac (Cataflam, Voltaren), etodolac (Lodine), indomethacin (Indocin), naproxen (Aleve, Naprosyn), meloxicam (Mobic), piroxicam (Feldene), and others.
This list is not complete and there may be other drugs that can interact with methotrexate. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.
Where can I get more information?
Your pharmacist can provide more information about methotrexate.
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.
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Additional Trexall Information
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
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