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Your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor or pharmacist first.

This drug should not be used with the following medications because very serious interactions may occur: high doses of aspirin and related drugs (salicylates), cidofovir, ketorolac, a certain weight loss drug (sibutramine).

If you are currently using any of these medications listed above, tell your doctor or pharmacist before starting this product.

Do not take this medication if you are taking MAO inhibitors (furazolidone, isocarboxazid, linezolid, moclobemide, phenelzine, procarbazine, rasagiline, selegiline, tranylcypromine) or if you have used MAO inhibitors in the past 2 weeks. In some cases a serious (possibly fatal) drug interaction may occur.

Before using this medication, tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use, especially of: anti-platelet drugs (such as cilostazol, clopidogrel), oral bisphosphonates (such as alendronate), "blood thinners" (such as enoxaparin, heparin, warfarin), corticosteroids (such as prednisone), cyclosporine, desmopressin, digoxin, drospirenone, drugs for high blood pressure (including ACE inhibitors such as captopril, angiotensin receptor blockers such as losartan, and beta-blockers such as metoprolol), lithium, methotrexate, pemetrexed, probenecid, SSRI antidepressants (such as fluoxetine, sertraline), NSRIs such as venlafaxine/duloxetine, tenofovir, "water pills" (diuretics such as furosemide, hydrochlorothiazide, triamterene).

Check all prescription and nonprescription medicine labels carefully for other pain/fever drugs (NSAIDs such as aspirin, celecoxib, ibuprofen). These drugs are similar to this medication, so taking one of these drugs while also taking this medication may increase your risk of side effects. However, if your doctor has prescribed low doses of aspirin to prevent heart attack or stroke (usually at dosages of 81-325 milligrams a day), you should continue to take the aspirin. Daily use of NSAIDs (such as ibuprofen) may decrease aspirin's ability to prevent heart attack/stroke. Consult your doctor or pharmacist for more details and to discuss other possible treatments (such as acetaminophen) for your pain/fever.

If you also take any ergotamine medication (such as dihydroergotamine or methysergide) or any other triptan drugs (such as zolmitriptan, rizatriptan), you will need to separate your sumatriptan dose from your dose of these other medications in order to lessen the chance of serious side effects. Ask your doctor how long you should wait between your doses of these drugs.

Also report the use of drugs which might increase seizure risk when combined with sumatriptan such as isoniazid (INH), phenothiazines (such as thioridazine), theophylline, or tricyclic antidepressants (such as amitriptyline) among others. Consult your doctor or pharmacist for details.

This medication can affect the results of certain lab tests (such as bleeding times, adrenal function tests). Make sure laboratory personnel and all your doctors know you use this drug.

This document does not contain all possible interactions. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and share the list with your doctor and pharmacist.

OVERDOSE: If overdose is suspected, contact your local poison control center or emergency room immediately. US residents can call the US National Poison Hotline at 1-800-222-1222. Canada residents can call a provincial poison control center. Symptoms of overdose may include: extreme drowsiness, slow/shallow breathing, seizures, shakiness (tremor).

NOTES: Do not share this medication with others. Certain foods/beverages or food additives (such as red wine, cheese, chocolate, monosodium glutamate) as well as some lifestyle patterns (such as irregular eating/sleeping habits, stress) may cause a migraine headache. Avoiding these "triggers" may help decrease the frequency of migraine headaches. Consult your doctor for more details.

Laboratory and/or medical tests (such as complete blood count, EKG, blood pressure, liver and kidney function tests) may be performed periodically to monitor your progress or check for side effects. Consult your doctor for more details.

MISSED DOSE: Take this medication only as needed when a migraine occurs, as directed by your doctor. This medication should not be taken on a regular schedule.

STORAGE: Store at room temperature at 77 degrees F (25 degrees C) away from light and moisture. Brief storage at 59-86 degrees F (15-30 degrees C) is permitted. Do not store in the bathroom. Keep all medications away from children and pets.

Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company for more details about how to safely discard your product.

Information last revised September 2010 Copyright(c) 2010 First DataBank, Inc.