April 28, 2016
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Patients (N = 670) have received single oral doses of 140 to 300 mg of sumatriptan without significant adverse effects. Volunteers (N = 174) have received single oral doses of 140 to 400 mg without serious adverse events.

Overdose of sumatriptan in animals has been fatal and has been heralded by convulsions, tremor, paralysis, inactivity, ptosis, erythema of the extremities, abnormal respiration, cyanosis, ataxia, mydriasis, salivation, and lacrimation.

In addition to the adverse events already described, significant naproxen overdosage may be characterized by lethargy, epigastric pain, abdominal discomfort, transient alterations in liver function, hypoprothrombinemia, metabolic acidosis, apnea, disorientation, or vomiting. Acute renal failure, respiratory depression, and coma may occur, but are rare.

Patients should be managed by symptomatic and supportive care. There are no specific antidotes. Hemodialysis does not decrease the plasma concentration of naproxen because of the high degree of its protein binding. It is unknown what effect hemodialysis or peritoneal dialysis has on the serum concentrations of sumatriptan. Forced diuresis, alkalinization of urine, or hemoperfusion may not be useful due to high protein binding.


TREXIMET is contraindicated in the following patients:

This monograph has been modified to include the generic and brand name in many instances.

Last reviewed on RxList: 9/10/2015


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