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In this Article

• What is sumatriptan and naproxen (Treximet)?
• What are the possible side effects of sumatriptan and naproxen (Treximet)?
• What is the most important information I should know about sumatriptan and naproxen
• What should I discuss with my health care provider before taking sumatriptan and naproxen (Treximet)?
• How should I take sumatriptan and naproxen (Treximet)?
• What happens if I miss a dose (Treximet)?
• What happens if I overdose (Treximet)?
• What should I avoid while taking sumatriptan and naproxen (Treximet)?
• What other drugs will affect sumatriptan and naproxen (Treximet)?
• Where can I get more information?

What happens if I miss a dose (Treximet)?

Since sumatriptan and naproxen is taken only when needed, it does not have a daily dosing schedule.

Do not take more than 2 sumatriptan and naproxen tablets in 24 hours.

What happens if I overdose (Treximet)?

Seek emergency medical attention if you think you have used too much of this medicine.

Symptoms of a sumatriptan and naproxen overdose are unknown, but may include dizziness, drowsiness, heartburn, stomach pain, nausea, vomiting, breathing problems, black or bloody stools, coughing up blood, and seizure (convulsions).

What should I avoid while taking sumatriptan and naproxen (Treximet)?

Do not use any other over-the-counter cold, allergy, or pain medication without first asking your doctor or pharmacist. Medicines available over the counter contain aspirin, naproxen, or other medicines similar to naproxen (such as ibuprofen or ketoprofen). If you take certain products together you may accidentally take too much of this type of medication. Read the label of any other medicine you are using to see if it contains aspirin, ibuprofen, ketoprofen, or naproxen.

Do not drink alcohol while taking sumatriptan and naproxen. Alcohol can increase the risk of stomach bleeding caused by naproxen.

Sumatriptan and naproxen can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert.

What other drugs will affect sumatriptan and naproxen (Treximet)?

Many drugs can interact with sumatriptan and naproxen. Below is just a partial list. Tell your doctor if you are using:

• a blood thinner such as warfarin (Coumadin);
• lithium (Eskalith, Lithobid);
• methotrexate (Rheumatrex, Trexall);
• probenecid (Benemid);
• a diuretic (water pill) such as furosemide (Lasix);
• steroids (prednisone and others);
• aspirin or other NSAIDs (non-steroidal anti-inflammatory drugs) such as diclofenac (Cataflam, Voltaren), etodolac (Lodine), indomethacin (Indocin), ketoprofen (Orudis), meloxicam (Mobic), and others;
• an ACE inhibitor such as benazepril (Lotensin), captopril (Capoten), fosinopril (Monopril), enalapril (Vasotec), lisinopril (Prinivil, Zestril), ramipril (Altace), and others;
• a beta-blocker such as atenolol (Tenormin), carvedilol (Coreg), metoprolol (Lopressor, Toprol), propranolol (Inderal, InnoPran), and others; or
• an antidepressant such as citalopram (Celexa), duloxetine (Cymbalta), escitalopram (Lexapro), fluoxetine (Prozac, Sarafem, Symbyax), paroxetine (Paxil), sertraline (Zoloft), or venlafaxine (Effexor).

This list is not complete and there may be other drugs that can interact with sumatriptan and naproxen. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

Where can I get more information?

Your pharmacist can provide more information about sumatriptan and naproxen.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed

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