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Tri-Luma

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Tri-Luma

Side Effects
Interactions

SIDE EFFECTS

Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in clinical practice.

In the controlled clinical trials, adverse events were monitored in the 161 subjects who used TRI-LUMA Cream once daily during an 8-week treatment period. There were 102 (63%) subjects who experienced at least one treatment-related adverse event during these trials. The most frequently reported events were erythema, desquamation, burning, dryness, and pruritus at the site of application. The majority of these events were mild to moderate in severity. Adverse events reported by at least 1% of patients and judged by the investigators to be reasonably related to treatment with TRI-LUMA Cream from the controlled clinical trials are summarized (in decreasing order of frequency) as follows:

Table 1: Incidence and Frequency of Treatment-related Adverse Events with TRI-LUMA Cream in at Least 1% or More of Subjects (N=161)

Adverse Event n (%)
Erythema 66 (41%)
Desquamation 61 (38%)
Burning 29 (18%)
Dryness 23 (14%)
Pruritus 18 (11%)
Acne 8 (5%)
Paresthesia 5 (3%)
Telangiectasia 5 (3%)
Hyperesthesia 3 (2%)
Pigmentary changes 3 (2%)
Irritation 3 (2%)
Papules 2 (1%)
Acne-like rash 1 (1%)
Rosacea 1 (1%)
Dry mouth 1 (1%)
Rash 1 (1%)
Vesicles 1 (1%)

In an open-label trial, subjects who had cumulative treatment of melasma with TRI-LUMA Cream for 6 months showed a similar pattern of adverse events as in the 8-week studies.

The following local adverse reactions have been reported with topical corticosteroids. They may occur more frequently with the use of occlusive dressings, especially with higher potency corticosteroids. These reactions are listed in an approximate decreasing order of occurrence: burning, itching, irritation, dryness, folliculitis, acneiform eruptions, hypopigmentation, perioral dermatitis, allergic contact dermatitis, secondary infection, skin atrophy, striae, and miliaria.

Read the Tri-Luma (hydroquinone 4% cream) Side Effects Center for a complete guide to possible side effects

DRUG INTERACTIONS

No information provided.

Read the Tri-Luma Drug Interactions Center for a complete guide to possible interactions

Last reviewed on RxList: 4/11/2014
This monograph has been modified to include the generic and brand name in many instances.

Side Effects
Interactions
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Tri-Luma - User Reviews

Tri-Luma User Reviews

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