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Tri-Sprintec Side Effects Center
Medical Editor: John P. Cunha, DO, FACOEP
Tri-Sprintec (norgestimate and ethinyl estradiol) is used as contraception to prevent pregnancy. It is also used to treat severe acne. Birth control pills have also been shown to make periods more regular, decrease blood loss and painful periods (dysmenorrhea), and decrease risk of ovarian cysts. Tri-Sprintec is a combination of the hormones estrogen and progesterone. Common side effects include nausea, vomiting, headache, stomach cramping/bloating, dizziness, vaginal discomfort, vaginal discharge, or breast tenderness/enlargement. Bleeding between periods (spotting) or missed/irregular periods may occur, especially during the first few months of use.
Tri-Sprintec is a 28-day regimen of tablets, taken as prescribed. Products that may adversely interact with Tri-Sprintec include aromatase inhibitors, raloxifene, sodium tetradecyl sulfate, tamoxifen, and medication for hypothyroidism. Drugs that may increase blood levels of Tri-Sprintec include acetaminophen, vitamin C, atorvastatin, and azole antifungals. Some medications may decrease birth control hormones in your body which can result in pregnancy, including griseofulvin, modafinil, rifamycins, St. John's wort, drugs used to treat seizures, and HIV drugs. Discuss all medications you are taking with your doctor. Tri-Sprintec must not be used during pregnancy. This medication passes into breast milk, may affect milk production, and may have undesirable effects on a nursing infant. Consult your doctor before breast-feeding.
Our Tri-Sprintec Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
What is Patient Information in Detail?
Easy-to-read and understand detailed drug information and pill images for the patient or caregiver from Cerner Multum.
Tri-Sprintec in Detail - Patient Information: Side Effects
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Stop using birth control pills and call your doctor at once if you have a serious side effect such as:
- sudden numbness or weakness, especially on one side of the body;
- sudden and severe headache, confusion, problems with vision, speech, or balance;
- chest pain or heavy feeling, pain spreading to the arm or shoulder, nausea, sweating, general ill feeling;
- sudden cough, wheezing, rapid breathing, coughing up blood;
- pain, swelling, warmth, or redness in one or both legs;
- a change in the pattern or severity of migraine headaches;
- nausea, upper stomach pain, itching, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);
- swelling in your hands, ankles, or feet;
- a breast lump; or
- symptoms of depression (sleep problems, weakness, tired feeling, mood changes).
Less serious side effects may include:
- mild nausea (especially when you first start taking this medicine), vomiting, bloating, stomach cramps;
- breast tenderness or swelling, nipple discharge;
- freckles or darkening of facial skin, increased hair growth, loss of scalp hair;
- changes in weight or appetite;
- problems with contact lenses;
- vaginal itching or discharge; or
- changes in your menstrual periods, decreased sex drive.
Read the entire detailed patient monograph for Tri-Sprintec (Norgestimate and Ethinyl Estradiol Tablets-Triphasic Regimen)
What is Patient Information Overview?
A concise overview of the drug for the patient or caregiver from First DataBank.
Tri-Sprintec Overview - Patient Information: Side Effects
Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.
Tell your doctor right away if you have any serious side effects, including: lumps in the breast, mental/mood changes (such as new/worsening depression), severe stomach/abdominal pain, unusual changes in vaginal bleeding (such as continuous spotting, sudden heavy bleeding, missed periods), dark urine, yellowing eyes/skin.
This medication may rarely cause serious (sometimes fatal) problems from blood clots (such as deep vein thrombosis, heart attack, pulmonary embolism, stroke). Get medical help right away if any of these side effects occur: chest/jaw/left arm pain, confusion, sudden dizziness/fainting, pain/swelling/warmth in the groin/calf, slurred speech, sudden shortness of breath/rapid breathing, unusual headaches (including headaches with vision changes/lack of coordination, worsening of migraines, sudden/very severe headaches), unusual sweating, weakness on one side of the body, vision problems/changes (such as double vision, partial/complete blindness).
A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.
This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.
In the US -
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.
Read the entire patient information overview for Tri-Sprintec (Norgestimate and Ethinyl Estradiol Tablets-Triphasic Regimen)
What is Prescribing information?
The FDA package insert formatted in easy-to-find categories for health professionals and clinicians.
Tri-Sprintec FDA Prescribing Information: Side Effects
An increased risk of the following serious adverse reactions has been associated with the use of oral contraceptives (See WARNINGS section).
The following adverse reactions have been reported in patients receiving oral contraceptives and are believed to be drug-related:
The following adverse reactions have been reported in users of oral contraceptives and the association has been neither confirmed nor refuted:
Read the entire FDA prescribing information for Tri-Sprintec (Norgestimate and Ethinyl Estradiol Tablets-Triphasic Regimen)
Additional Tri-Sprintec Information
Tri-Sprintec - User Reviews
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
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