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Symptoms of acute TRIDIONE overdosage include drowsiness, nausea, dizziness, ataxia, visual disturbances. Coma may follow massive overdosage.
Gastric evacuation, either by induced emesis, or by lavage, or both, should be done immediately. General supportive care, including frequent monitoring of the vital signs and close observations of the patient, are required.
Alkalinization of the urine has been reported to enhance the renal excretion of dimethadione, the active metabolite of TRIDIONE.
A blood count and a careful evaluation of hepatic and renal function should be done following recovery.
TRIDIONE is contraindicated in patients with a known hypersensitivity to the drug.
Last reviewed on RxList: 6/18/2012
This monograph has been modified to include the generic and brand name in many instances.
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