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Tridione Patient Information including How Should I Take

What should I discuss with my healthcare provider before taking trimethadione (Tridione)?

Before taking trimethadione, tell your doctor if you have

  • liver disease;
  • kidney disease;
  • retinal or optic nerve (eye) disease;
  • a disease of the blood or bone marrow; or
  • acute intermittent porphyria.

You may not be able to take trimethadione, or you may require a dosage adjustment or special monitoring during treatment if you have any of the conditions listed above.

Trimethadione is in the FDA pregnancy category D. This means that it is known to be harmful to an unborn baby. Malformations of the face and head, heart, and nervous system have been reported. Do not take trimethadione without first talking to your doctor if you are pregnant or could become pregnant during treatment.

It is not known whether trimethadione passes into breast milk and how it might affect a nursing infant. Do not use this medication without first talking to your doctor if you are breast-feeding a baby.

How should I take trimethadione (Tridione)?

Take trimethadione exactly as directed by your doctor. If you do not understand these directions, ask your pharmacist, nurse, or doctor to explain them to you.

Take each dose of trimethadione with a full glass of water.

Trimethadione can be taken on an empty stomach or with food to decrease stomach upset.

Chew the chewable tablets before swallowing them.

To ensure that you get a correct dose, measure the liquid form of trimethadione with a special dose-measuring spoon or cup, not with a regular table spoon. If you do not have a dose-measuring device, ask your pharmacist where you can get one.

Carry or wear a medical identification tag to let others know that you are taking this medicine in the case of an emergency.

Do not stop taking this medication even if you feel better. It is important to continue taking trimethadione to prevent the seizures from recurring.

Store trimethadione at room temperature away from moisture and heat.

Side Effects Centers

Report Problems to the Food and Drug Administration


You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.


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