"The U.S. Food and Drug Administration today approved a device to help reduce the frequency of seizures in epilepsy patients who have not responded well to medications.
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The following side effects, some of them serious, have been associated with the use of TRIDIONE (trimethadione).
Nausea, vomiting, abdominal pain, gastric distress.
Drowsiness, fatigue, malaise, insomnia, vertigo, headache, paresthesias, precipitation of grand mal seizures, increased irritability, personality changes.
Drowsiness usually subsides with continued therapy. If it persists, a reduction in dosage is indicated.
Bleeding gums, epistaxis, retinal and petechial hemorrhages, vaginal bleeding, neutropenia, leukopenia, eosinophilia, thrombocytopenia, pancytopenia, agranulocytosis, hypoplastic anemia, and fatal aplastic anemia.
Acneiform or morbilliform skin rash that may progress to exfoliative dermatitis or to severe forms of erythema multiforme.
Fatal nephrosis has occurred.
Hepatitis has been reported rarely.
Lupus erythematosus, and lymphadenopathies simulating malignant lymphoma, have been reported.
Pruritus associated with lymphadenopathy and hepatosplenomegaly has occurred in hypersensitive individuals.
A myasthenia gravis-like syndrome has been reported.
Read the Tridione (trimethadione tablets) Side Effects Center for a complete guide to possible side effects
No information provided.This monograph has been modified to include the generic and brand name in many instances.
Last reviewed on RxList: 2/8/2016
Additional Tridione Information
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