February 12, 2016
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Tridione

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Tridione




Tridione Side Effects Center

Medical Editor: John P. Cunha, DO, FACOEP

Last reviewed on RxList 2/8/2016

Tridione Dulcet (trimethadione) is an antiepileptic drug (AED) indicated for the control of petit mal seizures that do not respond to treatment with other drugs. Common side effects of Tridione Dulcet include nausea, sleepiness, tiredness, increase in seizures, feelings of anger and frustration, and changes in behavior. Tridione Dulcet can also cause many serious side effects. Tell your doctor if you have serious side effects of Tridione Dulcet, including droopy eyelids, rash, sensitivity to the sun, new joint or muscle pains, chest pain, shortness of breath, swelling of your feet/ankles/legs, weakness of your arms or legs, problems swallowing, speech problems, or swollen glands (enlarged lymph nodes). Antiepileptic drugs, including Tridione Dulcet, increase the risk of suicidal thoughts or behavior. Tell your doctor if this occurs. Do not suddenly stop taking Tridione Dulcet. Stopping the drug in a patient who has epilepsy can cause seizures that will not stop (status epilepticus).

The usual adult dosage of Tridione Dulcet is 0.9-2.4 grams daily in 3 or 4 equally divided doses (i.e., 300-600 mg 3 or 4 times daily). Tridione Dulcet may interact with other drugs that cause drowsiness, including antidepressants, alcohol, antihistamines, pain relievers, anxiety medicines, other seizure medicines, and muscle relaxants. Tell your doctor all medications and supplements you use. Tridione Dulcet is not recommended for use during pregnancy; it is known to cause birth defects. Women who can become pregnant should talk to their doctor about using other possible treatments instead of Tridione Dulcet. If Tridione Dulcet is used, talk to your doctor about effective birth control (contraception). Consult your doctor before breastfeeding.

Our Tridione Dulcet (trimethadione) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is Prescribing information?

The FDA package insert formatted in easy-to-find categories for health professionals and clinicians.

Tridione FDA Prescribing Information: Side Effects
(Adverse Reactions)

SIDE EFFECTS

The following side effects, some of them serious, have been associated with the use of TRIDIONE (trimethadione).

Gastrointestinal

Nausea, vomiting, abdominal pain, gastric distress.

CNS/Neurologic

Drowsiness, fatigue, malaise, insomnia, vertigo, headache, paresthesias, precipitation of grand mal seizures, increased irritability, personality changes.

Drowsiness usually subsides with continued therapy. If it persists, a reduction in dosage is indicated.

Hematologic

Bleeding gums, epistaxis, retinal and petechial hemorrhages, vaginal bleeding, neutropenia, leukopenia, eosinophilia, thrombocytopenia, pancytopenia, agranulocytosis, hypoplastic anemia, and fatal aplastic anemia.

Dermatologic

Acneiform or morbilliform skin rash that may progress to exfoliative dermatitis or to severe forms of erythema multiforme.

Other

Hiccups, anorexia, weight loss, hair loss, changes in blood pressure, albuminuria, hemeralopia, photophobia, diplopia.

Fatal nephrosis has occurred.

Hepatitis has been reported rarely.

Lupus erythematosus, and lymphadenopathies simulating malignant lymphoma, have been reported.

Pruritus associated with lymphadenopathy and hepatosplenomegaly has occurred in hypersensitive individuals.

A myasthenia gravis-like syndrome has been reported.

Read the entire FDA prescribing information for Tridione (Trimethadione Tablets)

Report Problems to the Food and Drug Administration

 

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.


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